Mfn2/Mitofusin 2 Antibody (XX-1): sc-100560

Mfn2 Antibody (XX-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Mitofusin 2 (Mfn2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Mfn2 antibody (XX-1) is available in a non-conjugated form, allowing for versatile experimental use. Mitofusin 2 plays a critical role in mitochondrial dynamics, specifically in mitochondrial fusion, which maintains mitochondrial function and cellular energy homeostasis. Mfn2 (XX-1) monoclonal antibody recognizes proteins primarily located in the outer mitochondrial membrane, where Mfn2 facilitates the merging of adjacent mitochondria, promoting mitochondrial integrity and function. This process is particularly important in tissues with high energy demands, such as heart and muscle, where efficient mitochondrial function is crucial for overall cellular health. Dysregulation of Mitofusin 2 has been implicated in various pathologies, including neurodegenerative diseases and metabolic disorders, highlighting Mfn2′s significance in both normal physiology and disease states. Mitofusin 2 interacts with several other proteins involved in mitochondrial dynamics and cellular signaling, underscoring Mfn2′s role as a key player in mitochondrial regulation.

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Mfn2/Mitofusin 2 Antibody (XX-1) References:

1. Control of mitochondrial morphology by a human mitofusin.  |  Santel, A. and Fuller, MT. 2001. J Cell Sci. 114: 867-74. PMID: 11181170
2. Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.  |  Rojo, M., et al. 2002. J Cell Sci. 115: 1663-74. PMID: 11950885
3. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.  |  Chen, H., et al. 2003. J Cell Biol. 160: 189-200. PMID: 12527753
4. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.  |  Bach, D., et al. 2003. J Biol Chem. 278: 17190-7. PMID: 12598526
5. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.  |  Santel, A., et al. 2003. J Cell Sci. 116: 2763-74. PMID: 12759376
6. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity.  |  Ishihara, N., et al. 2004. J Cell Sci. 117: 6535-46. PMID: 15572413
7. The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.  |  Hu, Y., et al. 2021. Autophagy. 17: 1142-1156. PMID: 32249716
8. Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIδ pathway in vitro and in vivo.  |  Song, Z., et al. 2022. Theranostics. 12: 1267-1285. PMID: 35154486
9. The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology.  |  Zaman, M. and Shutt, TE. 2022. Front Cell Dev Biol. 10: 858286. PMID: 35399520
10. MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1.  |  Tang, Y., et al. 2022. Circ Res. 130: e26-e43. PMID: 35450439
11. Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors.  |  Yang, JF., et al. 2023. Sci Immunol. 8: eabq2424. PMID: 37738362
12. DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress.  |  Yepuri, G., et al. 2023. Nat Commun. 14: 6900. PMID: 37903764

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mfn2/Mitofusin 2 Antibody (XX-1) has 118 citations in a variety of scientific publications.

Primary antibodies like Anti-Mfn2/Mitofusin 2 Antibody (XX-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mfn2/Mitofusin 2 Antibody (XX-1) Specifications

Alternate Product Name: Mitofusin-2

Product Clone Name: XX-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 661-757

Epitope Target: Mfn2

Epitope Species: human

Product Reactivity/Detection: Mitofusin 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 118 citations in various scientific publications

Available Conjugates/Forms for Mfn2/Mitofusin 2 Antibody (XX-1): N/A

The preferred Mfn2/Mitofusin 2 antibody is Mfn2/Mitofusin 2 Antibody (F-5): sc-515647.