MFG-E8 Antibody (2B62): sc-71573
- MFG-E8 Antibody (2B62) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against human milk fat globule membrane tissue / cell preparation
- recommended for detection of MFG-E8 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for MFG-E8 Antibody (2B62) for WB and IHC(P) applications. This reagent is now offered in a bundle with MFG-E8 Antibody (2B62) (see ordering information below).
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MFG-E8 Antibody (2B62) is a mouse monoclonal IgG1 antibody that detects MFG-E8 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MFG-E8, also known as Milk fat globule-EGF factor 8 or Lactadherin, is a 387 amino acid peripheral membrane protein that plays a crucial role in cellular interactions and signaling. MFG-E8 is primarily located on the membranes of mammary epithelial cells and other tissues, where MFG-E8 serves as a specific ligand for Integrin β5 and Integrin β3, facilitating important processes such as cell attachment and potentially influencing fertilization and apoptosis. The structural composition of MFG-E8, which includes one EGF-like domain and two F5/8 type C domains, is vital for function, as these domains enable MFG-E8 to interact effectively with integrins and other cellular components. MFG-E8 has been shown to bind to rotavirus, inhibiting replication and thereby providing a protective mechanism against viral infections. Notably, overexpression of MFG-E8 has been linked to breast cancer, indicating potential involvement in tumorigenesis and making MFG-E8 a significant target for research in cancer biology.
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MFG-E8 Antibody (2B62) References:
- MFG-E8 accelerates wound healing in diabetes by regulating 'NLRP3 inflammasome-neutrophil extracellular traps' axis. | Huang, W., et al. 2020. Cell Death Discov. 6: 84. PMID: 32963812
- Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. | Ikemoto-Uezumi, M., et al. 2022. Aging Cell. 21: e13536. PMID: 34953020
- MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling. | Chiang, HY., et al. 2022. Commun Biol. 5: 364. PMID: 35440618
- MFG-E8 Reduces Aortic Intimal Proliferation in a Murine Model of Transplant Vasculopathy. | Brilland, B., et al. 2022. Int J Mol Sci. 23: PMID: 35456911
- High Levels of MFG-E8 Confer a Good Prognosis in Prostate and Renal Cancer Patients. | Geoffroy, K., et al. 2022. Cancers (Basel). 14: PMID: 35681775
- MFG-E8 has guiding significance for the prognosis and treatment of sepsis. | Wu, W., et al. 2022. Sci Rep. 12: 20916. PMID: 36463380
- MFG-E8: a model of multiple binding modes associated with ps-binding proteins. | Suwatthee, T., et al. 2023. Eur Phys J E Soft Matter. 46: 114. PMID: 37999806
- Methylated MFGE8 Promotes Early Brain Injury After Subarachnoid Hemorrhage and Inhibiting Autophagy of Nerve Cell. | Zou, L., et al. 2023. Transl Stroke Res.. PMID: 38095841
- MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells. | Liu, W., et al. 2024. Eur J Pharmacol. 969: 176462. PMID: 38431242
- Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. | Ma, Z., et al. 2024. Cell Commun Signal. 22: 295. PMID: 38802814
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MFG-E8 Antibody (2B62) | sc-71573 | 200 µg/ml | $322.00 | |||
MFG-E8 Antibody (2B62): m-IgG Fc BP-HRP Bundle | sc-539376 | 200 µg Ab; 10 µg BP | $361.00 |