Lutropin β Antibody (B-6): sc-374017
- Lutropin β Antibody (B-6) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 109-135 near the C-terminus of Lutropin β of rat origin
- recommended for detection of Lutropin β of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Lutropin β Antibody (B-6) for WB applications. This reagent is now offered in a bundle with Lutropin β Antibody (B-6) (see ordering information below).
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Lutropin β Antibody (B-6) is a mouse monoclonal IgG3 antibody that detects Lutropin β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lutropin β, also known as luteinizing hormone (LH), is crucial for reproductive health as anti-Lutropin β antibody (B-6) plays a significant role in regulating the reproductive system by stimulating the production of sex steroids in the testes and ovaries, thereby facilitating processes such as spermatogenesis and ovulation. The structure of Lutropin β is particularly important, as Lutropin β monoclonal antibody (B-6) recognizes a heterodimer composed of a common alpha chain and a unique beta chain, which is essential for biological activity and receptor binding. Different isoforms of LH, resulting from proteolytic processing, highlight the complexity of regulation and function in the endocrine system. Additionally, Lutropin β has been shown to influence the processing of amyloid-beta precursor protein, which is relevant in the context of neurodegenerative diseases, making Lutropin β (B-6) antibody an invaluable tool for researchers investigating multifaceted roles in both reproductive and neurological contexts.
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Lutropin β Antibody (B-6) References:
- The contribution of luteinizing hormone to Alzheimer disease pathogenesis. | Webber, KM., et al. 2007. Clin Med Res. 5: 177-83. PMID: 18056027
- A carboxyl-terminal sequence in the lutropin beta subunit contributes to the sorting of lutropin to the regulated pathway. | Jablonka-Shariff, A., et al. 2008. J Biol Chem. 283: 11485-92. PMID: 18292086
- Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. | Arnhold, IJ., et al. 2009. Horm Res. 71: 75-82. PMID: 19129711
- The action of luteinizing hormone on the testis. | Neuman, I., et al. 1991. J Steroid Biochem Mol Biol. 40: 441-51. PMID: 1958545
- Luteinizing hormone acts at the hippocampus to dampen spatial memory. | Burnham, V., et al. 2017. Horm Behav. 89: 55-63. PMID: 27847314
- Structural studies on equine glycoprotein hormones. Amino acid sequence of equine lutropin beta-subunit. | Bousfield, GR., et al. 1987. J Biol Chem. 262: 8610-20. PMID: 3298239
- Luteinizing hormone and the aging brain. | Mey, M., et al. 2021. Vitam Horm. 115: 89-104. PMID: 33706966
- Characterization of cleavage products in selected human lutropin preparations. A protease-sensitive site in human lutropin beta subunit. | Ward, DN., et al. 1986. Int J Pept Protein Res. 27: 70-8. PMID: 3512464
- Luteinizing Hormone Dynamics in Menstruation. | Lee, I., et al. 2022. Annu Int Conf IEEE Eng Med Biol Soc. 2022: 2270-2273. PMID: 36086664
- The lutropin beta-subunit N-terminus facilitates subunit combination by offsetting the inhibitory effects of residues needed for LH activity. | Slaughter, S., et al. 1995. Mol Cell Endocrinol. 112: 21-5. PMID: 7589781
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lutropin β Antibody (B-6) | sc-374017 | 200 µg/ml | $322.00 | |||
Lutropin β Antibody (B-6): m-IgG3 BP-HRP Bundle | sc-550446 | 200 µg Ab; 40 µg BP | $361.00 | |||
Lutropin β (B-6) Neutralizing Peptide | sc-374017 P | 100 µg/0.5 ml | $69.00 |