Lipoic Acid Antibody (13C5): sc-101354

Lipoic Acid Antibody (13C5) is a mouse monoclonal IgM antibody that detects Lipoic Acid protein of non-species reactive (NSR) by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Lipoic Acid antibody (13C5) is available as a non-conjugated format. Lipoic Acid, also known as alpha-lipoic acid, is a vital organic sulfur-containing fatty acid that plays a crucial role in cellular metabolism, particularly in the pyruvate dehydrogenase complex, where Lipoic Acid facilitates the conversion of pyruvate to acetyl-CoA. This function is essential for energy production and the synthesis of fatty acids and amino acids, making Lipoic Acid indispensable for aerobic life. Moreover, Lipoic Acid is known for antioxidant properties, which help to neutralize free radicals and reduce oxidative stress, thereby contributing to neuroprotection and anti-inflammatory effects. These properties make Lipoic Acid a promising candidate for therapeutic interventions in neurodegenerative diseases such as Alzheimer′s Disease, Parkinson′s Disease, and Multiple Sclerosis. Additionally, Lipoic Acid′s ability to chelate heavy metals, particularly mercury, underscores Lipoic Acid′s importance in detoxification processes. As a common dietary supplement, Lipoic Acid can be found in various foods, including spinach, potatoes, broccoli, and organ meats like liver, heart, and kidney, further highlighting Lipoic Acid′s significance in human health.

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Lipoic Acid Antibody (13C5) References:

1. Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.  |  Lal, A., et al. 2008. Redox Rep. 13: 2-10. PMID: 18284845
2. Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis.  |  Yang, RL., et al. 2008. Nutrition. 24: 582-8. PMID: 18367378
3. Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.  |  Salinthone, S., et al. 2008. Endocr Metab Immune Disord Drug Targets. 8: 132-42. PMID: 18537699
4. The role of lipoic acid in prevention of nitroglycerin tolerance.  |  Dudek, M., et al. 2008. Eur J Pharmacol. 591: 203-10. PMID: 18616939
5. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.  |  Maczurek, A., et al. 2008. Adv Drug Deliv Rev. 60: 1463-70. PMID: 18655815
6. Lipoic acid rescues DBA mice from early-onset age-related hearing impairment.  |  Ahn, JH., et al. 2008. Neuroreport. 19: 1265-9. PMID: 18695505
7. Lipoic acid metabolism and mitochondrial redox regulation.  |  Solmonson, A. and DeBerardinis, RJ. 2018. J Biol Chem. 293: 7522-7530. PMID: 29191830
8. Lipoic acid. Kinetics and pluripotent biological properties and derivatives.  |  Theodosis-Nobelos, P., et al. 2021. Mol Biol Rep. 48: 6539-6550. PMID: 34420148
9. Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review.  |  Abubaker, SA., et al. 2022. Cureus. 14: e25750. PMID: 35812639
10. Hypersensitivity to lipoic acid.  |  Marchi, F. and Carabelli, A. 2023. Eur Ann Allergy Clin Immunol.. PMID: 37671889
11. The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress.  |  Akpinar, D., et al. 2008. Physiol Res. 57: 893-901. PMID: 18052687
12. Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.  |  Zhang, H., et al. 2010. J Cell Mol Med. 14: 215-25. PMID: 20414966

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lipoic Acid Antibody (13C5) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lipoic Acid Antibody (13C5) Specifications

Alternate Product Name: Lipoic Acid

Product Clone Name: 13C5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Lipoic Acid

Epitope Species:

Product Reactivity/Detection: free and bound Lipoic Acid

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgM in 500 µl of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Lipoic Acid Antibody (13C5): N/A