Integrin β2/ITGB2/CD18 Antibody (6A21): sc-71398

Integrin β2 Antibody (6A21) is a mouse monoclonal IgG1 antibody that detects Integrin β2 in human samples through applications such as western blotting (non-reducing), immunoprecipitation, immunofluorescence, and flow cytometry. Integrin β2 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Specifically, anti-Integrin β2 antibody (6A21) pairs with various α subunits to form receptors that play a vital role in cell adhesion and signaling. Integrin β2 is predominantly located on the cell surface, where Integrin β2 interacts with ligands in the extracellular matrix, such as Fibronectin and Collagen, as well as with counterreceptors on adjacent cells. This localization is essential for mediating cellular responses to the extracellular environment, influencing processes such as cell migration, proliferation, and survival. Furthermore, Integrin β2 is involved in the immune response, particularly in leukocyte adhesion and migration, which are critical for effective immune surveillance and response to inflammation. The ability of Integrin β2 to facilitate these interactions underscores its importance in both normal physiological processes and pathological conditions, making Integrin β2 a significant target for research and therapeutic interventions. Integrin β2 monoclonal antibody (6A21) provides a reliable tool for studying these complex biological functions and the underlying mechanisms of integrin-mediated signaling.

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Integrin β2/ITGB2/CD18 Antibody (6A21) References:

1. Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion.  |  Lefer, AM. 1999. Ann Thorac Surg. 68: 1920-3. PMID: 10585104
2. Attenuation of leukocyte beta 2-integrin expression by antithrombin-III.  |  Gritti, D., et al. 2004. Int J Immunopathol Pharmacol. 17: 27-32. PMID: 15000863
3. The CD11/CD18 (beta2) integrins modulate neutrophil caspase activation and survival following TNF-alpha or endotoxin induced transendothelial migration.  |  Yan, SR., et al. 2004. Immunol Cell Biol. 82: 435-46. PMID: 15283855
4. Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice.  |  Peters, T., et al. 2006. J Leukoc Biol. 80: 599-607. PMID: 16844762
5. Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects.  |  Liang, Y., et al. 2008. Blood. 111: 954-62. PMID: 17928532
6. Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human β2 integrins and erythrocytes.  |  Reinholdt, J., et al. 2013. Biochim Biophys Acta. 1834: 546-58. PMID: 23234758
7. The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.  |  Morrison, VL., et al. 2013. Blood. 122: 1428-36. PMID: 23823319
8. Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase.  |  Li, R., et al. 2016. J Proteome Res. 15: 4221-4233. PMID: 27690452
9. β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.  |  Blythe, EN., et al. 2021. Front Immunol. 12: 775447. PMID: 34858434
10. In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltration and injury by a beta2 integrin-dependent mechanism.  |  Zhou, MY., et al. 1998. J Clin Invest. 101: 2427-37. PMID: 9616214

The preferred Integrin β2/ITGB2/CD18 antibody is Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420.