Integrin αL/ITGAL/CD11a Antibody (16B8): sc-18830
- Integrin αL/ITGAL/CD11a Antibody (16B8) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against human PBLs, Jurkat tumor cells and human enriched T lymphocytes
- recommended for detection of Integrin αL of human origin by IF
- also provided azide-free for inhibiting the proliferation of PMNs and the response to soluble CD3 monoclonals, sc-18830 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin αL/ITGAL/CD11a Antibody (16B8). This work is in progress.
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Integrin αL Antibody (16B8) is a mouse monoclonal IgG2a light chain antibody that detects Integrin αL in human samples through immunofluorescence (IF) applications. Integrin αL, also called CD11a, is a crucial component of the immune system, primarily expressed on leukocytes, where Integrin αL plays a vital role in mediating cell adhesion and migration. Integrin αL is located on the cell surface, where Integrin αL interacts with various ligands, including intercellular adhesion molecules (ICAMs), facilitating the adhesion of leukocytes to endothelial cells during immune responses. Proper functioning of Integrin αL is essential for leukocyte trafficking to sites of inflammation, which is critical for effective immune surveillance and response. Dysregulation of Integrin αL can lead to impaired immune responses and has been implicated in various inflammatory diseases. Anti-Integrin αL antibody (16B8) is an invaluable tool for researchers studying immune cell behavior, providing insights into the mechanisms of cell adhesion and migration in both health and disease.
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Integrin αL/ITGAL/CD11a Antibody (16B8) References:
- Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1. | Geng, X., et al. 2005. Immunology. 115: 347-57. PMID: 15946252
- Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemia. | Zhou, Y., et al. 2012. Am J Clin Pathol. 138: 744-50. PMID: 23086776
- Sepsis-induced leukocyte adhesion in the pulmonary microvasculature in vivo is mediated by CD11a and CD11b. | Wang, Y., et al. 2013. Eur J Pharmacol. 702: 135-41. PMID: 23380685
- Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis. | Wang, Y., et al. 2014. Clin Epigenetics. 6: 25. PMID: 25414732
- CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. | Shukla, AK., et al. 2019. Glia. 67: 844-856. PMID: 30588668
- Expression of CD11a and CD45R isoforms defines distinct subsets of CD8+ TCR alpha beta and TCR gamma delta CTL in vivo. | Hedlund, G., et al. 1995. Immunol Rev. 146: 82-94. PMID: 7493762
- Administration of anti-TNF-alpha or anti-CD11a antibodies to normal adult mice decreases lung and bone collagen content: evidence for an effect on platelet consumption. | Piguet, PF., et al. 1995. Am J Respir Cell Mol Biol. 12: 227-31. PMID: 7532421
- CD11a/CD18 (LFA-1) integrin engagement enhances biosynthesis of early cytokines by activated T cells. | Fan, ST., et al. 1993. Cell Immunol. 148: 48-59. PMID: 8098668
- A peptide from ICAM-2 binds to the leukocyte integrin CD11a/CD18 and inhibits endothelial cell adhesion. | Li, R., et al. 1993. J Biol Chem. 268: 17513-8. PMID: 8349630
- The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. | Qu, A. and Leahy, DJ. 1996. Structure. 4: 931-42. PMID: 8805579
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin αL/ITGAL/CD11a Antibody (16B8) | sc-18830 | 200 µg/ml | $322.00 | |||
Integrin αL/ITGAL/CD11a Antibody (16B8) L | sc-18830 L | 200 µg/0.1 ml | $322.00 |