Integrin α6/ITGA6/CD49f Antibody (NKI-GOH3): sc-80554

Integrin α6 Antibody (NKI-GOH3) is a rat monoclonal IgG2a antibody designed to target the extracellular epitope of human Integrin α6, also known as CD49f. Integrin α6 monoclonal antibody (NKI-GOH3) exhibits broad species reactivity, effectively recognizing Integrin α6 in mouse, rat, and human samples when applied in immunofluorescence (IF) and flow cytometry (FCM) assays. Integrin α6 is a crucial component of the integrin family, functioning as a heterodimer typically paired with β1 or β4 subunits to form receptors involved in cell adhesion and signaling. A significant post-translational modification of Integrin α6 is glycosylation, which plays a vital role in stability, ligand binding affinity, and cellular localization. Glycosylation of Integrin α6 enhances interaction with extracellular matrix components such as laminins, facilitating processes like cell migration, differentiation, and tissue organization. Additionally, glycosylation state of Integrin α6 can influence signal transduction by modulating interactions with intracellular signaling molecules, affecting cell growth and apoptosis. This makes Integrin α6 a key player in various biological pathways and disease mechanisms. Integrin α6 (NKI-GOH3) antibody is an essential tool for researchers studying these processes, providing reliable detection and quantification across multiple species. By targeting a critical extracellular region, anti-Integrin α6 antibody (NKI-GOH3) aids in elucidating functional roles in cellular adhesion, cytoskeletal organization, and signal transduction. Overall, Integrin α6 monoclonal antibody (NKI-GOH3) is indispensable for advancing our understanding of integrin-mediated cellular functions and their implications in health and disease.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.