Integrin α4/ITGA4/CD49d Antibody (9F10): sc-23933
- Integrin α4/ITGA4/CD49d Antibody (9F10) is a mouse monoclonal IgG1, cited in 2 publications, provided at 200 µg/ml
- raised against immunopurified Integrin α4b (VLA-4) of human origin
- recommended for detection of Integrin α4 of human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α4/ITGA4/CD49d Antibody (9F10). This work is in progress.
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Integrin α4 Antibody (9F10) is a mouse monoclonal IgG1 antibody that detects Integrin α4 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α4 plays a crucial role in cell adhesion and migration by mediating interactions between cells and the extracellular matrix, particularly in the context of immune responses and inflammation. Anti-Integrin α4 antibody (9F10) recognizes this protein primarily on the surface of leukocytes, where Integrin α4 facilitates adhesion to endothelial cells and the extracellular matrix, which is essential for the recruitment of immune cells to sites of injury or infection. The ability of Integrin α4 to bind to ligands, such as vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, is vital for proper immune system functioning, as Integrin α4 influences processes like lymphocyte trafficking and tissue infiltration. Anti-Integrin α4 antibody (9F10) enables researchers to gain insights into the mechanisms of immune cell behavior and the pathophysiology of various diseases, including autoimmune disorders and cancer.
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Integrin α4/ITGA4/CD49d Antibody (9F10) References:
- Role of integrin alpha4 in drug resistance of leukemia. | Shishido, S., et al. 2014. Front Oncol. 4: 99. PMID: 24904821
- Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. | Young, SA., et al. 2015. PLoS One. 10: e0120815. PMID: 25973900
- Integrin α4 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF-C in Human Colon Cancer. | Lv, XH., et al. 2016. Anat Rec (Hoboken). 299: 741-7. PMID: 26917449
- Multiple non-catalytic ADAMs are novel integrin α4 ligands. | Wang, L., et al. 2018. Mol Cell Biochem. 442: 29-38. PMID: 28913673
- Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype. | Lord, JD., et al. 2018. Clin Immunol. 193: 24-32. PMID: 29842945
- Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis. | Schumacher, JA., et al. 2020. Dev Biol. 465: 46-57. PMID: 32628938
- CD47- and Integrin α4/β1-Comodified-Macrophage-Membrane-Coated Nanoparticles Enable Delivery of Colchicine to Atherosclerotic Plaque. | Li, Y., et al. 2022. Adv Healthc Mater. 11: e2101788. PMID: 34786845
- Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6. | Wu, L., et al. 2022. Vascul Pharmacol. 147: 107113. PMID: 36184060
- Mesenchymal stem cell aggregation mediated by integrin α4/VCAM-1 after intrathecal transplantation in MCAO rats. | Ran, Y., et al. 2022. Stem Cell Res Ther. 13: 507. PMID: 36273220
- Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. | Hipke, K., et al. 2023. Front Cell Dev Biol. 11: 1169962. PMID: 37384248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α4/ITGA4/CD49d Antibody (9F10) | sc-23933 | 200 µg/ml | $322.00 | |||
Integrin α4/ITGA4/CD49d Antibody (9F10) FITC | sc-23933 FITC | 200 µg/ml | $336.00 | |||
Integrin α4/ITGA4/CD49d Antibody (9F10) PE | sc-23933 PE | 200 µg/ml | $349.00 |