Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
insulin Rα Antibody (83-12) is a high quality monoclonal insulin R alpha antibody (also designated insulin Rα antibody) suitable for the detection of the insulin R alpha protein of human origin. insulin Rα Antibody (83-12) is available as both the non-conjugated anti-insulin R alpha antibody form, as well as multiple conjugated forms of anti-insulin R alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.2 and encodes a 1382 amino acid protein that cleaves to form alpha and beta subunits. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can sc-57343: insulin Rα(83-12) differs insulin receptor A from insulin receptor B in western blot? It seems that there is few specific antibody of IR-A.
Preguntado por: YouMaru
Thank you for your question. This monoclonal insulin Rα Antibody (83-12): sc-57343 is specific for insulin Rα and recommended for use in immunoprecipitation (IP).
Respondida por: Technical Support
Fecha de publicación: 2018-12-06
What is the recommended secondary reagent to be used with sc-57343: insulin Rα (83-12) mouse monoclonal primary?
Preguntado por: TinTin
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here:
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