IL-1α Anticuerpo (G-10) es un monoclonal de ratón IgG1 κ, ver las 2 publicaciones, proporcionado como 200 µg/ml
específico para un epítopo localizado entre los amino ácidos 239-269 en el C-terminus de IL-1å de origen human
IL-1 alpha Anticuerpo (G-10) es recomendado para detectar IL-1α de human origen, mediante WB, IP, IF, IHC(P) y ELISA
IL-1 alpha Anticuerpo (G-10) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de IL-1α (G-10): sc-271618.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IL-1α Antibody (G-10) for WB and IHC(P) applications. These reagents are now offered in bundles with IL-1α Antibody (G-10) (see ordering information below).
IL-1 para análisis funcionales de las repuestas celulares a IL-1
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Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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