IL-11 Antibody (F-3): sc-133084

IL-11 Antibody (F-3) is a mouse monoclonal IgG2a antibody that detects interleukin-11 (IL-11) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-11 is a pleiotropic cytokine that plays a crucial role in hematopoiesis and immune regulation, particularly in the proliferation of primitive hematopoietic progenitor cells. IL-11 (F-3) antibody recognizes a cytokine secreted by stromal cells that′s essential for expanding CD34+ cell populations, which are vital for developing various blood cell lineages. The human IL-11 gene encodes a 199 amino acid precursor that includes a 21 amino acid hydrophobic signal peptide, which is cleaved to produce a biologically active, glycosylated form of IL-11. The functional significance of IL-11 is underscored by interaction with interleukin-11 receptor (IL-11R), which consists of an IL-11 receptor-specific chain, IL-11Rα, and signal transducing component gp130. Upon binding to IL-11R, IL-11 activates Janus tyrosine kinases JAK1 and JAK2, leading to nuclear translocation of transcription factors Stat1 and Stat3, which are critical for mediating downstream effects of IL-11 in various physiological and pathological processes. Anti-IL-11 antibody (F-3) serves as an invaluable tool for researchers studying IL-11′s role in hematopoiesis and implications in diseases such as fibrosis and inflammation.

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IL-11 Antibody (F-3) References:

1. Endogenous interleukin-11 (IL-11) levels in newly diagnosed children with acquired severe aplastic anemia (SAA).  |  Cockrell, EM., et al. 2004. Cytokine. 28: 55-8. PMID: 15381181
2. Plasma interleukin-11 (IL-11) levels have diagnostic and prognostic roles in patients with pancreatic cancer.  |  Ren, C., et al. 2014. Tumour Biol. 35: 11467-72. PMID: 25123265
3. Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation.  |  Lokau, J., et al. 2016. Mediators Inflamm. 2016: 1785021. PMID: 27493449
4. The cytokine interleukin-11 crucially links bone formation, remodeling and resorption.  |  Kespohl, B., et al. 2021. Cytokine Growth Factor Rev. 60: 18-27. PMID: 33940443
5. Elevated interleukin-11 in systemic sclerosis and role in disease pathogenesis.  |  Steadman, T. and O'Reilly, S. 2023. J Dermatol. 50: 1255-1261. PMID: 37291792
6. Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.  |  Singh, A., et al. 2023. Invest Ophthalmol Vis Sci. 64: 1. PMID: 37910094
7. Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.  |  Metcalfe, RD., et al. 2023. Nat Commun. 14: 7543. PMID: 37985757
8. Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.  |  Gardner, S., et al. 2024. Nat Commun. 15: 2071. PMID: 38453915
9. Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.  |  Ng, B., et al. 2024. Nat Commun. 15: 8530. PMID: 39358385
10. IL-11-An aging-related cytokine with opportunities for regulating hematopoiesis.  |  Kent, DG. 2024. Hemasphere. 8: e70050. PMID: 39564540

The preferred IL-11 antibody is IL-11 Antibody (A-9): sc-133063.