producido contra los amino ácidos 123-200 de IGF-IRα de origen human
IGF-1 Receptor α/IGF1R Anticuerpo (G-5) es recomendado para detectar IGF-IRα de mouse, rat y human origen, mediante WB, IP, IF, IHC(P) y ELISA
IGF-1 Receptor α/IGF1R Anticuerpo (G-5) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de IGF-1 Receptor α/IGF1R (G-5): sc-271606.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IGF-1 Receptor α/IGF1R Antibody (G-5) for WB and IHC(P) applications. These reagents are now offered in bundles with IGF-1 Receptor α/IGF1R Antibody (G-5) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IGF-IRα Antibody (G-5) is a high quality monoclonal IGF-IR alpha antibody (also designated IGF1R antibody, insulin like growth factor 1 receptor antibody, or CD221 antibody) suitable for the detection of the IGF-IR alpha protein of mouse, rat and human origin. IGF-IRα Antibody (G-5) is available as both the non-conjugated anti-IGF-IR alpha antibody form, as well as multiple conjugated forms of anti-IGF-IR alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into α and β subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences