HAPLN4 Antibody (H-6): sc-271450

HAPLN4 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects HAPLN4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HAPLN4 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HAPLN4, or Hyaluronan and proteoglycan link protein 4, is a 360 amino acid protein encoded by the human gene HAPLN4 and is a member of the HAPLN family, characterized by one immunoglobulin-like C2-type domain and two Link domains. HAPLN4 plays a crucial role in mediating the binding of hyaluronic acid complexes, particularly facilitating the strong interaction between versican V2 and hyaluronic acid. HAPLN4 serves a pivotal function in the formation of the hyaluronan-associated matrix within the central nervous system (CNS), which is essential for neuronal conduction and structural stabilization. HAPLN4 contributes to the formation of extracellular matrices that are vital for the development of perineuronal nets, thereby enhancing our understanding of the functional roles these matrices play in neural environments. HAPLN4 is widely expressed, with the highest levels found in the spleen and placenta, underscoring its significance in various biological processes.

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HAPLN4 Antibody (H-6) References:

1. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.  |  Hirakawa, S., et al. 2000. Biochem Biophys Res Commun. 276: 982-9. PMID: 11027579
2. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.  |  Nomoto, H., et al. 2002. Acta Med Okayama. 56: 25-9. PMID: 11873941
3. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.  |  Spicer, AP., et al. 2003. J Biol Chem. 278: 21083-91. PMID: 12663660
4. [Bral1, Bral2: the novel brain specific-hyaluronan and protoglycan link protein genes].  |  Oohashi, T., et al. 2004. Tanpakushitsu Kakusan Koso. 49: 2354-61. PMID: 15552986
5. Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components.  |  Carulli, D., et al. 2006. J Comp Neurol. 494: 559-77. PMID: 16374793
6. Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum.  |  Carulli, D., et al. 2007. J Comp Neurol. 501: 83-94. PMID: 17206619
7. Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.  |  Sim, H., et al. 2009. J Biol Chem. 284: 26547-56. PMID: 19633295
8. Identification of candidate genes for familial early-onset essential tremor.  |  Liu, X., et al. 2016. Eur J Hum Genet. 24: 1009-15. PMID: 26508575
9. The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model.  |  Liu, L., et al. 2020. PLoS One. 15: e0243911. PMID: 33326461
10. Identification of genetic variants influencing methylation in brain with pleiotropic effects on psychiatric disorders.  |  Pineda-Cirera, L., et al. 2022. Prog Neuropsychopharmacol Biol Psychiatry. 113: 110454. PMID: 34637873
11. Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders.  |  Li, X., et al. 2023. Schizophr Bull. 49: 1305-1315. PMID: 37418754
12. Production of hyaluronan-dependent pericellular matrix by embryonic rat glial cells.  |  Deyst, KA. and Toole, BP. 1995. Brain Res Dev Brain Res. 88: 122-5. PMID: 7493403

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HAPLN4 Antibody (H-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HAPLN4 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HAPLN4 Antibody (H-6) Specifications

Alternate Product Name: HAPLN4

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 229-273

Epitope Target: HAPLN4

Epitope Species: human

Product Reactivity/Detection: HAPLN4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HAPLN4 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin