H2-I/Adβ Antibody (5K43): sc-71202
- H2-I/Adβ Antibody (5K43) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 100 µg/ml
- raised against C57BL/6 x DBA/2)F1 splenocytes of mouse origin
- recommended for detection of H2-I/Adβ of mouse origin by WB, IP and FCM; may cross-react with H2-I/Ab
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-I/Adβ Antibody (5K43). This work is in progress.
H2-I/Adβ Antibody (5K43) is a mouse monoclonal IgG2a antibody that detects H2-I/Adβ in mouse samples through western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). H2-I/Adβ is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting foreign peptides to cytotoxic T lymphocytes (CTLs). The structure of H2-I/Adβ, as a beta chain precursor, is essential for the formation of the MHC class II complex, which consists of both alpha and beta chains. This structural arrangement is significant because it determines the specificity and efficiency of antigen presentation, ultimately influencing T cell activation and the adaptive immune response. Anti-H2-I/Adβ antibody (5K43) enables researchers to gain insights into the mechanisms of immune recognition and response, making this tool invaluable for studies in immunology and related fields.
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H2-I/Adβ Antibody (5K43) References:
- Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin. | Wang, J., et al. 2002. J Biol Chem. 277: 1433-42. PMID: 11696552
- Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production. | Kessler, B., et al. 2003. J Biol Chem. 278: 10013-21. PMID: 12488316
- Molecular comparisons of the beta 2-microglobulin-binding site in class I major-histocompatibility-complex alpha-chains and proteins of related sequences. | Tysoe-Calnon, VA., et al. 1991. Biochem J. 277 (Pt 2): 359-69. PMID: 1859364
- Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice. | Mellor, AL., et al. 1991. Int Immunol. 3: 493-502. PMID: 1911536
- The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H-2Dd, not Qa/Tla. | Brickell, PM., et al. Nature. 316: 162-3. PMID: 2989712
- Structure of the murine CD94-NKG2A receptor in complex with Qa-1b presenting an MHC-I leader peptide. | MacLachlan, BJ., et al. 2024. FEBS J. 291: 1530-1544. PMID: 38158698
- NK cell recognition of major histocompatibility complex class I molecules. | Lanier, LL. and Phillips, JH. 1995. Semin Immunol. 7: 75-82. PMID: 7579197
- A second lineage of mammalian major histocompatibility complex class I genes. | Bahram, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 6259-63. PMID: 8022771
- Binding of H-2Kb-specific peptides to TAP and major histocompatibility complex class I in microsomes from wild-type, TAP1, and beta2-microglobulin mutant mice. | Wang, P., et al. 1996. J Biol Chem. 271: 24830-5. PMID: 8798757
- Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts. | Seliger, B., et al. 1998. Eur J Immunol. 28: 122-33. PMID: 9485192
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-I/Adβ Antibody (5K43) | sc-71202 | 100 µg/ml | $322.00 |