Molecular structure of GP 2A, CAS Number: 919077-81-9
GP 2A (CAS 919077-81-9)
Alternate Names:
N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Application:
GP 2A is a selective CB2 agonist that also shows modest agonism at CB1 receptors
CAS Number:
919077-81-9
Purity:
≥99%
Molecular Weight:
440.36
Molecular Formula:
C24H23Cl2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
GP 2A is a selective CB2 receptor agonist. Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. GP 2A increases P-ERK1/2 expression in HL-60 cells in vitro.
GP 2A (CAS 919077-81-9) References
- Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. | Ramachandran, R., et al. 2009. Mol Pharmacol. 76: 791-801. PMID: 19605524
- A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. | Fujita, T., et al. 2011. J Invest Dermatol. 131: 1660-7. PMID: 21593768
- Differential modulation of GABA(A) receptor function by aryl pyrazoles. | Mascia, MP., et al. 2014. Eur J Pharmacol. 733: 1-6. PMID: 24704372
- The CB2 receptor and its role as a regulator of inflammation. | Turcotte, C., et al. 2016. Cell Mol Life Sci. 73: 4449-4470. PMID: 27402121
- Gaq proteins: molecular pharmacology and therapeutic potential. | Kamato, D., et al. 2017. Cell Mol Life Sci. 74: 1379-1390. PMID: 27815595
Activator of:
CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GP 2A, 10 mg | sc-203588 | 10 mg | $410.00 | |||
| US: Only available in the US | ||||||
GP 2A, 50 mg | sc-203588A | 50 mg | $1250.00 | |||
| US: Only available in the US | ||||||