Date published: 2026-7-28

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Glycylglycine, Free Base (CAS 556-50-3)

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Alternate Names:
2-[(2-aminoacetyl)amino]acetic acid
Application:
Glycylglycine, Free Base is a dipeptide used as a buffering reagent
CAS Number:
556-50-3
Purity:
≥99%
Molecular Weight:
132.12
Molecular Formula:
C4H8N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Glycylglycine (Gly-Gly) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Also useful as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.


Glycylglycine, Free Base (CAS 556-50-3) References

  1. Mutation analysis of the histidine residues in the glycylglycine endopeptidase ALE-1.  |  Fujiwara, T., et al. 2005. J Bacteriol. 187: 480-7. PMID: 15629919
  2. Glycylglycine decreases the size of conspicuous facial pores: Single-blinded half areas of face-applied study.  |  Iida, T., et al. 2009. J Dermatol. 36: 120-3. PMID: 19284462
  3. Photoemission and photoabsorption spectroscopy of glycyl-glycine in the gas phase.  |  Feyer, V., et al. 2009. J Phys Chem A. 113: 10726-33. PMID: 19757775
  4. Studies of enthalpy-entropy compensation, partial entropies, and Kirkwood-Buff integrals for aqueous solutions of glycine, L-leucine, and glycylglycine at 298.15 K.  |  Kurhe, DN., et al. 2009. J Phys Chem B. 113: 16612-21. PMID: 19924870
  5. Rat kidney brush border enzyme activity following subchronic oral lead exposure.  |  Teichert-Kuliszewska, K. and Nicholls, DM. 1985. Toxicol Appl Pharmacol. 77: 211-8. PMID: 2858132
  6. Metal-ligated amino acids and peptides as substrates for proteases.  |  Bagger, S. 1987. Int J Pept Protein Res. 30: 99-101. PMID: 3667081
  7. Energetics of glycylglycine transport in Escherichia coli.  |  Cowell, JL. 1974. J Bacteriol. 120: 139-46. PMID: 4278690
  8. Differential modulation of rat heart mitochondrial membrane-associated enzymes by dietary lipid.  |  McMurchie, EJ., et al. 1983. Biochim Biophys Acta. 760: 13-24. PMID: 6311280
  9. Isoelectric focusing of immunoglobulins: improved methodology.  |  Nicolotti, RA., et al. 1980. J Immunol Methods. 33: 101-15. PMID: 6768804
  10. Impairment of jejunal absorption rate of carnosine by glycylglycine in man in vivo.  |  Cook, GC. 1976. Gut. 17: 252-7. PMID: 773786

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Glycylglycine, Free Base, 25 g

sc-202633
25 g
$29.00

Glycylglycine, Free Base, 100 g

sc-202633A
100 g
$71.00