GCKR Antibody (A-8): sc-74552

GCKR Antibody (A-8) is a mouse monoclonal IgG2a antibody that detects glucokinase regulatory protein (GCKR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GCKR plays a crucial role in the regulation of glucokinase, which is essential for glucose metabolism and insulin secretion. By modulating the activity of glucokinase, GCKR helps maintain glucose homeostasis, making GCKR vital for preventing conditions such as hyperglycemia and diabetes. GCKR is primarily located in the liver and pancreatic tissues, where GCKR interacts with glucokinase to fine-tune insulin release in response to blood glucose levels. Understanding the function and regulation of GCKR is important for elucidating the mechanisms underlying metabolic disorders, particularly maturity onset diabetes of the youth (MODY), which can arise from mutations affecting glucokinase activity. Anti-GCKR antibody (A-8) is an invaluable tool for researchers investigating the intricate pathways of glucose regulation and the potential therapeutic targets for diabetes management.

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GCKR Antibody (A-8) References:

1. Glucokinase regulatory protein is associated with mitochondria in hepatocytes.  |  Arden, C., et al. 2006. FEBS Lett. 580: 2065-70. PMID: 16542652
2. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.  |  Santoro, N., et al. 2012. Hepatology. 55: 781-9. PMID: 22105854
3. Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.  |  Li, H., et al. 2013. Mol Biol Rep. 40: 3935-42. PMID: 23307301
4. Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR).  |  Wang, ZY., et al. 2013. PLoS One. 8: e60896. PMID: 23573289
5. Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity.  |  Chen, K., et al. 2014. J Biomol Screen. 19: 1014-23. PMID: 24717911
6. Early gene-diet interaction between glucokinase regulatory protein (GCKR) polymorphism, vegetable and fish intakes in modulating triglyceride levels in healthy adolescents.  |  Tam, CH., et al. 2015. Nutr Metab Cardiovasc Dis. 25: 951-8. PMID: 26234566
7. Theoretical investigations on the interactions of glucokinase regulatory protein with fructose phosphates.  |  Ling, B., et al. 2016. Comput Biol Chem. 60: 21-31. PMID: 26629747
8. Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.  |  Martinez, JA., et al. 2017. Biochemistry. 56: 3150-3157. PMID: 28516783
9. Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.  |  Watanabe, H., et al. 2018. Nat Commun. 9: 30. PMID: 29296001
10. Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus.  |  Brown, KS., et al. 1997. Diabetes. 46: 179-86. PMID: 9000692

The preferred GCKR antibody is GCKR Antibody (B-9): sc-166841.