GCDFP-15 Antibody (C-12): sc-377171

GCDFP-15 Antibody (C-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects GCDFP-15 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GCDFP-15 (C-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gross cystic disease fluid protein 15 (GCDFP-15), also known as prolactin inducible protein (PIP), plays a crucial role in regulating cellular processes related to breast tissue, particularly in breast cancer, where GCDFP-15 serves as a significant biomarker. GCDFP-15 is primarily expressed in exocrine glands and is found in various bodily fluids, including saliva, tears, and sweat, highlighting GCDFP-15′s importance in physiological and pathological conditions. GCDFP-15 is detectable in approximately 50% of breast cancer specimens, making GCDFP-15 a valuable target for cancer diagnostics. The PIP gene, which encodes GCDFP-15, is located on chromosome 7′s long arm, a region often altered in mammary tumors, underscoring GCDFP-15′s relevance in oncogenic processes. GCDFP-15′s ability to interact with other proteins involved in cellular signaling pathways further emphasizes GCDFP-15′s potential role in cancer progression and treatment response, making anti-GCDFP-15 antibody (C-12) an essential tool for researchers studying breast cancer and related diseases.

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GCDFP-15 Antibody (C-12) References:

1. Regulation of GCDFP-15 expression in human mammary cancer cells.  |  Loos, S., et al. 1999. Int J Mol Med. 4: 135-40. PMID: 10402478
2. Biosynthesis and immunobiochemical characterization of gp17/GCDFP-15. A glycoprotein from seminal vesicles and from breast tumors, in HeLa cells and in Pichia pastoris yeast.  |  Caputo, E., et al. 1999. Eur J Biochem. 265: 664-70. PMID: 10504398
3. Immunohistochemical analysis of GCDFP-15 and GCDFP-24 in mammary and non-mammary tissue.  |  Satoh, F., et al. 2000. Breast Cancer. 7: 49-55. PMID: 11029771
4. Identification of mouse submaxillary gland protein in mouse saliva and its binding to mouse oral bacteria.  |  Lee, B., et al. 2002. Arch Oral Biol. 47: 327-32. PMID: 11922875
5. Intragenic amplification and formation of extrachromosomal small circular DNA molecules from the PIP gene on chromosome 7 in primary breast carcinomas.  |  Autiero, M., et al. 2002. Int J Cancer. 99: 370-7. PMID: 11992405
6. GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors.  |  Wang, LJ., et al. 2009. Appl Immunohistochem Mol Morphol. 17: 505-11. PMID: 19620839
7. Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes.  |  Darb-Esfahani, S., et al. 2014. BMC Cancer. 14: 546. PMID: 25070172
8. Breast gross cystic disease fluid analysis. I. Isolation and radioimmunoassay for a major component protein.  |  Haagensen, DE., et al. 1979. J Natl Cancer Inst. 62: 239-47. PMID: 283260
9. Gross Cystic Disease Fluid Protein-15 (GCDFP-15) Expression Characterizes Breast Mucinous Carcinomas in Older Women.  |  Kinoshita, M., et al. 2022. Diagnostics (Basel). 12: PMID: 36553136
10. Immunoexpression of the GCDFP-15 Marker in Different Grades of Breast Carcinoma.  |  Shirian, F., et al. 2023. Iran J Pathol. 18: 75-81. PMID: 37383152
11. Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features.  |  Mazoujian, G., et al. 1983. Am J Pathol. 110: 105-12. PMID: 6130702
12. Analysis of amniotic fluid, maternal plasma, and cord blood for a human breast gross cystic disease fluid protein.  |  Haagensen, DE., et al. 1980. Am J Obstet Gynecol. 138: 25-32. PMID: 7416203

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GCDFP-15 Antibody (C-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GCDFP-15 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GCDFP-15 Antibody (C-12) Specifications

Alternate Product Name: GCDFP-15

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-146

Epitope Target: GCDFP-15

Epitope Species: mouse

Product Reactivity/Detection: GCDFP-15

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GCDFP-15 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin