GCAP2 Antibody (A1): sc-59543

GCAP2 Antibody (A1) is a mouse monoclonal IgG2a antibody that detects guanylate cyclase-activating protein 2 (GCAP2) in bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). GCAP2 plays a crucial role in the regulation of phototransduction in the retina, specifically in the outer segments of photoreceptor cells, where GCAP2 is involved in the recovery of the dark state after exposure to light. GCAP2 is essential for maintaining proper levels of cyclic guanosine monophosphate (cGMP), which is vital for photoreceptor functioning. The structure of GCAP2, consisting of 201 to 205 amino acids and featuring three conserved calcium-binding sites, allows GCAP2 to respond to fluctuations in intracellular calcium levels, thereby modulating activity. GCAP2 is closely related to GCAP1, with over 90% similarity, and is exclusively expressed in the retina, highlighting a specialized function in visual signaling. The genes encoding GCAP1 and GCAP2 are located on human chromosome 6p21.1, and understanding the interactions and regulatory mechanisms of these proteins is important for elucidating the molecular basis of retinal function and potential pathologies. Anti-GCAP2 antibody (A1) is an invaluable tool for researchers studying the dynamics of phototransduction and the role of calcium-binding proteins in visual processes.

The preferred GCAP2 antibody is GCAP2 Antibody (G-10): sc-166056.