galectin-2 Antibody (C6): sc-517450

galectin-2 Antibody (C6) is a mouse monoclonal IgG2b kappa light chain antibody that detects galectin-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-galectin-2 antibody (C6) is available as a non-conjugated format. Galectins, including galectin-2, are a family of soluble β-galactoside-binding lectins that play crucial roles in various biological processes, such as cell-to-cell adhesion and interactions with the extracellular matrix, which are vital for maintaining tissue integrity and regulating immune responses. Galectin-2, also known as LGALS2, Lactose-binding lectin 2, or HL14, is primarily expressed in the gastrointestinal tract and is structurally similar to galectin-1. Notably, galectin-2 has been shown to induce apoptosis in activated T cells and interacts with cytokine lymphotoxin-α (LTA), suggesting involvement in immune regulation and potential implications in myocardial infarction risk. The ability of galectin-2 to modulate immune cell behavior highlights importance in both normal physiology and pathological conditions, making galectin-2 (C6) antibody a valuable tool for researchers studying these processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

galectin-2 Antibody (C6) References:

1. Potential roles of galectins in myeloid differentiation into three different lineages.  |  Abedin, MJ., et al. 2003. J Leukoc Biol. 73: 650-6. PMID: 12714580
2. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.  |  Ozaki, K., et al. 2004. Nature. 429: 72-5. PMID: 15129282
3. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation.  |  Sturm, A., et al. 2004. J Immunol. 173: 3825-37. PMID: 15356130
4. Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.  |  Hirabayashi, J., et al. 1989. Biochim Biophys Acta. 1008: 85-91. PMID: 2719964
5. Molecular cloning, characterization, and expression of a human 14-kDa lectin.  |  Couraud, PO., et al. 1989. J Biol Chem. 264: 1310-6. PMID: 2910856
6. Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.  |  Mehrabian, M., et al. 1993. Genomics. 15: 418-20. PMID: 8449510
7. Production and characterization of a monoclonal antibody able to discriminate galectin-1 from galectin-2 and galectin-3.  |  Cornillot, JD., et al. 1998. Glycobiology. 8: 425-32. PMID: 9597540
8. Identification and cloning of rat galectin-2: expression is predominantly in epithelial cells of the stomach.  |  Oka, T., et al. 1999. Arch Biochem Biophys. 361: 195-201. PMID: 9882446

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-galectin-2 Antibody (C6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-galectin-2 Antibody (C6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

galectin-2 Antibody (C6) Specifications

Alternate Product Name: galectin-2

Product Clone Name: C6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-132

Epitope Target: galectin-2

Epitope Species: human

Product Reactivity/Detection: galectin-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for galectin-2 Antibody (C6): N/A