Furin Anticuerpo (B-6): sc-133142

Furin Antibody (B-6) is a high quality monoclonal Furin antibody (also designated Paired Basic Amino Acid Cleaving Enzyme antibody, Paired Basic Amino Acid Residue-Cleaving Enzyme antibody, PCSK3 antibody, Furin antibody, PACE antibody, SPC1 antibody, FUR antibody, Paired Basic Amino Acid Cleaving Enzyme antibody, Furin (Paired Basic Amino Acid Cleaving Enzyme) antibody, Proprotein Convertase Subtilisin/Kexin Type 3 antibody, Dibasic Processing Enzyme antibody, Dibasic-Processing Enzyme antibody, or FES Upstream Region antibody) suitable for the detection of the Furin protein of mouse, rat and human origin. Furin Antibody (B-6) is available as both the non-conjugated anti-Furin antibody form, as well as multiple conjugated forms of anti-Furin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Furin (FUR, PACE, PCSK3, SPC1, Kex2p) is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. Furin can directly cleave proMMP-2 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2). Furin is synthesized as an inactive zymogen that may minimize the occurrence of premature enzymatic activity that would lead to alternative protein activation or degradation. The inhibitory mechanism is based on the presence of an inactivating prosegment at the NH2 terminal of the Furin. After initial autocatalytic cleavage, the prosegment remains tightly associated until it reaches the trans-Golgi network where the dissociation of the prosegment and activation of furin occurs.

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