Molecular structure of Fluconazole, CAS Number: 86386-73-4
Fluconazole (CAS 86386-73-4)
See product citations (14)
Alternate Names:
a-(2,4-Difluorophenyl)-a-(1H-1,2,4-triazol-1- ylmethyl)-1H-1,2,4-triazole-1-ethanol
Application:
Fluconazole is a triazole broad-spectrum antifungal agent particularly for candida species
CAS Number:
86386-73-4
Purity:
≥98%
Molecular Weight:
306.27
Molecular Formula:
C13H12F2N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluconazole is a triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4. Fluconazole functions by suppressing the production of ergosterol, a vital constituent of the fungal cell membrane. By impeding ergosterol synthesis, the integrity of the fungal cell membrane is compromised, ultimately resulting in fungal death. Moreover, Fluconazole hinders the activity of cytochrome P450 enzymes.
Fluconazole (CAS 86386-73-4) References
- The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review. | Martin, MV. 1999. J Antimicrob Chemother. 44: 429-37. PMID: 10588302
- Fluconazole. Review and situation among antifungal drugs in the treatment of opportunistic mycoses of human immuno-deficiency virus infections. | Vincent-Ballereau, FN., et al. 1991. Pharm Weekbl Sci. 13: 45-57. PMID: 1870943
- Comparison of flucytosine and fluconazole combined with amphotericin B for the treatment of HIV-associated cryptococcal meningitis: a systematic review and meta-analysis. | Yao, ZW., et al. 2014. Eur J Clin Microbiol Infect Dis. 33: 1339-44. PMID: 24550039
- Anidulafungin versus fluconazole: clinical focus on IDSA and ESCMID guidelines. | De Rosa, FG., et al. 2014. Infez Med. 22: 107-11. PMID: 24955796
- Toxic epidermal necrolysis in a neonate receiving fluconazole. | Islam, S., et al. 2014. J Perinatol. 34: 792-4. PMID: 25263725
- Is Fluconazole or an Echinocandin the Agent of Choice for Candidemia. | Eschenauer, GA., et al. 2015. Ann Pharmacother. 49: 1068-74. PMID: 26104051
- Novel fluconazole derivatives with promising antifungal activity. | Thamban Chandrika, N., et al. 2018. Bioorg Med Chem. 26: 573-580. PMID: 29279242
- The effect of fluconazole on oral methadone in dogs. | KuKanich, B., et al. 2019. Vet Anaesth Analg. 46: 501-509. PMID: 30982709
- Influence of Fluconazole Administration on Gut Microbiome, Intestinal Barrier, and Immune Response in Mice. | Heng, X., et al. 2021. Antimicrob Agents Chemother. 65: PMID: 33722893
- Direct Fluconazole Disk Susceptibility Testing for Candida glabrata-Positive Blood Cultures. | Israel, S., et al. 2021. J Clin Microbiol. 59: e0031121. PMID: 33883184
- Early versus Late Fluconazole Prophylaxis in Autologous Hematopoietic Cell Transplantation. | Guarana, M., et al. 2021. Transplant Cell Ther. 27: 681.e1-681.e5. PMID: 33964515
- Serotonin reuptake inhibitors effect on fluconazole activity against resistant Candida glabrata strains. | Alkhalifa, BA., et al. 2022. J Glob Antimicrob Resist. 29: 49-54. PMID: 35181564
- Promising fluconazole based zinc(II) and copper(II) coordination polymers against Chagas disease. | de Azevedo-França, JA., et al. 2022. J Inorg Biochem. 233: 111834. PMID: 35500350
- Fluconazole as Schistosoma mansoni cytochrome P450 inhibitor: In vivo murine experimental study. | Elzoheiry, MA., et al. 2022. Exp Parasitol. 239: 108291. PMID: 35660528
- Pharmacokinetics of fluconazole after oral administration to healthy beagle dogs. | Choi, Y., et al. 2022. Vet Dermatol. 33: 509-515. PMID: 36000582
- Chelerythrine reverses the drug resistance of resistant Candida albicans and the biofilm to fluconazole. | Gong, Y., et al. 2022. Future Microbiol. 17: 1325-1333. PMID: 36111728
- Impact of concomitant fluconazole on direct oral anticoagulant bleeding risk. | Cid, A., et al. 2022. Pharmacotherapy. 42: 880-889. PMID: 36271717
Inhibitor of:
CIDE-A, CRABP-II, CRS1C-3, Cyclosporin A, CYP1A2, CYP20A1, Cyp21a1, CYP26, CYP26C1, CYP27B1, CYP27C1, CYP2AB1, CYP2B19, CYP2B23, CYP2B9, CYP2C18, CYP2C19, Cyp2c29, Cyp2c37, Cyp2c38, Cyp2c39, Cyp2c40, Cyp2c44, Cyp2c50, Cyp2c55, Cyp2c65, Cyp2c66, Cyp2c67, Cyp2c68, Cyp2c69, Cyp2c70, CYP2C9, CYP2D12, CYP2D40, CYP2G1, CYP2J12, CYP2J13, CYP2J5, CYP2J6, CYP2J7, CYP2J8, CYP2J9, CYP2S1, CYP2T4, CYP2U1, CYP39A1, CYP3A, CYP3A1, Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a18, CYP3A4, Cyp3a41a, Cyp3a41b, Cyp3a44, Cyp3a57, Cyp3a59, CYP46, CYP4A14, CYP4AA2, CYP4AA3, CYP4B1, CYP4F11, Cyp4f16, Cyp4f17, CYP4F22, CYP4F3, Cyp4f37, Cyp4f39, Cyp4f40, CYP4V2, CYP4X1, CYP4Z1, CYP51A1, Cyp60, CYP8B1, CyPA, CYPOR, DDTL, EG226604, ERG25, FK-506, Histatin 2, ISX, MOXD1, Olfr825, Olfr951, Olfr963, Olr210, Olr235, Pdr5, Sm E, Ssn6, StAR, TFPI, TREK-2, UGT1A10, UGT1A3, UGT1A5, UGT2A3, UGT2B, UGT2B1, and UGT3A1.Activator of:
Candida albicans, CYP26, Cyp2c54, CYP51A1, Fumonisin, and PIG-C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluconazole, 500 mg | sc-205698 | 500 mg | $54.00 | |||
Fluconazole, 1 g | sc-205698A | 1 g | $84.00 |