DDEF1 Antibody (P7Q): sc-81896
- DDEF1 Antibody (P7Q) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant DDEF1 of human origin
- recommended for detection of DDEF1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DDEF1 Antibody (P7Q). This work is in progress.
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DDEF1 Antibody (P7Q) is a mouse monoclonal IgG2a antibody that detects DDEF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDEF1, also known as development and differentiation enhancing factor 1, ASAP1, AMAP1, or PAG2, is a crucial ADP ribosylation factor (ARF)-GTPase activating protein (GAP) that plays a significant role in cellular signaling pathways. DDEF1 is primarily localized in the cytoplasm and at newly formed focal complexes at the cell periphery, where DDEF1 interacts with various signaling proteins, including ARF1, ARF5, ARF6, and SRK (ZAP-70). These interactions are vital for regulating cell motility and actin cytoskeletal remodeling, as well as influencing the differentiation of adipocytes and fibroblasts. The structural composition of DDEF1 includes two ankyrin repeats, one ARF-GAP domain, one SH3 domain, and one PH domain, which are essential for the phosphoinositide-dependent regulation of ARFs. Notably, overexpression of DDEF1 has been associated with the inhibition of invasion and metastasis in breast cancer and high-grade uveal melanomas, highlighting DDEF1′s potential as a therapeutic target and diagnostic marker in oncology. Anti-DDEF1 antibody (P7Q) is an invaluable tool for researchers investigating the intricate roles of DDEF1 in cancer biology and cellular differentiation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DDEF1 Antibody (P7Q) | sc-81896 | 100 µg/ml | $339.00 |