connexin 46 Antibody (D-6): sc-377361

Connexin 46 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects connexin 46 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Connexin 46 plays a crucial role in the formation of gap junctions, which are essential for intercellular communication, particularly in the lens of the eye where connexin 46 facilitates the transfer of small molecules and ions between adjacent cells. This communication is vital for maintaining lens transparency and overall eye health; disruptions in connexin 46 expression can lead to severe conditions such as cataracts. Connexin 46 is primarily located in the plasma membrane of lens epithelial cells, where connexin 46 forms hexameric complexes known as connexons, allowing for the passage of signaling molecules that are critical for cellular homeostasis. The unique structure of connexin 46, characterized by four transmembrane α-helical domains and specific extracellular loops, contributes to distinct permeability properties, which are essential for proper functioning of the lens. Given the importance of connexin 46 in maintaining lens integrity, anti-connexin 46 antibody (D-6) serves as a valuable tool for researchers investigating molecular mechanisms underlying lens development and pathology.

The preferred connexin 46 antibody is connexin 46 Antibody (C-3): sc-365394.