connexin 43 Antibody (CXN-6): sc-59949

connexin 43 Antibody (CXN-6) is a mouse monoclonal IgM antibody that detects connexin 43 in mouse, rat, human, and bovine samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. anti-connexin 43 antibody (CXN-6) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. Connexin 43, also known as GJA1, is a crucial gap junction protein that forms hexameric structures called connexons, which facilitate direct intercellular communication by allowing the passage of low molecular weight molecules between adjacent cells. This function is particularly important in maintaining tissue homeostasis and coordinating cellular responses, especially in cardiac and neuronal tissues. Notably, connexin 43 undergoes various post-translational modifications, including phosphorylation, which can significantly influence function and interactions. During mitosis, connexin 43 undergoes specific phosphorylation that correlates with a temporary loss of gap junction intercellular communication, highlighting a dynamic role in cellular processes. Additionally, phosphorylation of connexin 43 on tyrosine residues, particularly by activated c-Src, has been shown to inhibit gap junctional communication, which is often disrupted in malignant cells, thereby linking connexin 43 to cancer progression. Connexin 43′s ability to interact with other proteins, such as c-Src, further underscores importance in cellular signaling pathways and regulation of gap junction communication.

The preferred connexin 43 antibody is connexin 43 Antibody (D-7): sc-13558.