clasto-Lactacystin beta-lactone CAS: 155975-72-7
MF: C10H15NO4
MW: 213.23
A 20S proteasome and cathepsin A inhibitor.

clasto-Lactacystin β-lactone (CAS 155975-72-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 128ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
clasto-Lactacystin β-lactone is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Nombres Alternativos: Omuralide; clasto-Lactacystin |A-lactone; Clasto-lactacystin(Omuralide)
Solicitud: clasto-Lactacystin β-lactone is a 20S proteasome and cathepsin A inhibitor
Número de CAS: 155975-72-7
Pureza: >95%
Peso Molecular: 213.23
Fórmula Molecular: C10H15NO4
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

clasto-Lactacystin β-lactone, a synthetic derivative of lactahydrin, is a cell permeable, irreversible and specific inhibitor of the 20S proteasome involved in the ubiquitin-proteasome degradation pathway. Kinetic studies indicate that clasto-Lactacystin β-lactone interacts with the proteasome at its catalytic site threonines, which opens the β-lactone ring and allows the proteasome's catalytic hydroxyl group to become acylated. clasto-Lactacystin β-lactone has been reported to rapidly enter cells in mammalian cell culture media and to additionally inactivate the proteasome in Jurkat cells in a dose-dependent manner. In addition, clasto-Lactacystin β-lactone is reported to inhibit cathepsin A, lead to adipogenesis and induce neurite growth in rat PC12 cells.


References

1. Fenteany, G., et al. 1995. Science. 268: 726-731. PMID: 7732382
2. Dick, L.R., et al. 1997. J. Biol. Chem. 272: 182-188. PMID: 8995245
3. Obin, M., et al. 1999. J. Biol. Chem. 274: 11789-11795. PMID: 10206996
4. Kisselev, A.F., et al. 2001. Chem. Biol. 8: 739-758. PMID: 11514224

Uso :
Soluble in DMSO. DMSO stock solutions can be diluted using a pH 7 buffer, however do not use after one day due to gradual hydrolysis in aqueous media. Store at -20C for up to two years, and protect from light.
Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (25 mg/ml), and acetonitrile.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
161.31° C (Predicted)
Punto de ebullición :
440.82° C at 760 mmHg
Densidad :
1.28 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.52 (Predicted)
IC50 :
Oryctolagus cuniculus: IC50 = 57 nM; Ubiquitin proteasome pathway: IC50 = 1 µM; HEK293: IC50 = 1.6 µM (human); RPMI-8226: IC50 = 3.3 µM (human)
Valores de pK :
pKa: 13.33 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
2
PubChem CID :
9794358
Número MDL :
MFCD01076526
SMILES :

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

clasto-Lactacystin beta-lactone (CAS 155975-72-7)  Menciones del Producto

Ver como otros han utilizado clasto-Lactacystin beta-lactone (CAS 155975-72-7). Haga click en la entrada de PubMed .

Citaciones 1 a 1 de un total de 1

PMID: # 28261569  Rucks, EA. et al. 2017. Frontiers in cellular and infection microbiology. 7: 40.

Citaciones 1 a 1 de un total de 1
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. es un líder mundial en el desarrollo de productos para el mercado de la investigación biomédica. Llámenos gratis al 00 800 4573 8000.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved."Santa Cruz Biotechnology", y el logo de Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", el logo de San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", y "EZ Touch" son marcas registradas de Santa Cruz Biotechnology, Inc. Todas las marcas registradas son propiedad de su respectivo dueño.