Molecular structure of Chrysin, CAS Number: 480-40-0
Chrysin (CAS 480-40-0)
See product citations (13)
Alternate Names:
5,7-Dihydroxyflavone
Application:
Chrysin is an inhibitor of HIF-1α (hypoxia-inducible factor-1α)
CAS Number:
480-40-0
Purity:
98%
Molecular Weight:
254.24
Molecular Formula:
C15H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Chrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi present in various plants such as honey, propolis, and the passionflower vine. In vitro research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis.
Chrysin (CAS 480-40-0) References
- Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. | Woo, KJ., et al. 2004. Biochem Biophys Res Commun. 325: 1215-22. PMID: 15555556
- [Preparation of a prekallikrein concentrate and determination of its activator in blood derivatives]. | Simonianová, E. 1992. Cesk Farm. 41: 8-9. PMID: 1586974
- Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. | Moon, YJ., et al. 2006. Toxicol In Vitro. 20: 187-210. PMID: 16289744
- Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis. | Fu, B., et al. 2007. Mol Cancer Ther. 6: 220-6. PMID: 17237281
- Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action. | Mani, R. and Natesan, V. 2018. Phytochemistry. 145: 187-196. PMID: 29161583
- Impact of chrysin on the molecular mechanisms underlying diabetic complications. | Farkhondeh, T., et al. 2019. J Cell Physiol. 234: 17144-17158. PMID: 30916403
- Chrysin: Pharmacological and therapeutic properties. | Naz, S., et al. 2019. Life Sci. 235: 116797. PMID: 31472146
- Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice. | Zhou, YJ., et al. 2021. J Agric Food Chem. 69: 5618-5627. PMID: 33979145
- Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent. | Stompor-Gorący, M., et al. 2021. Nutrients. 13: PMID: 34198618
- Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells. | Zhou, L., et al. 2021. Biochem Pharmacol. 193: 114813. PMID: 34673014
- Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review. | Dewi, RM., et al. 2022. Mini Rev Med Chem. 22: 1450-1457. PMID: 34720081
- Chrysin: A polyedric flavone as a tool to explore new phytotherapeutic applications and drug design. | Falbo, F. and Aiello, F. 2023. Arch Pharm (Weinheim). 356: e2200347. PMID: 36316229
- Structure-antioxidant activity relationships of flavonoids and phenolic acids. | Rice-Evans, CA., et al. 1996. Free Radic Biol Med. 20: 933-56. PMID: 8743980
Inhibitor of:
α-actinin-1, β-defensin 3B, β-defensin 41, β-Glucoronidase, γ-casein, ABCG2, AKR7A3, APOBEC3B, B7-H3, brain and placenta PFK-2, Chemokine Receptor D6, CYP1A1, DAX-1, EG574081, FOXM1, G6pd2, GATA-4, GILZ, Glut7, Gm694, GRK 5, GRO, Gsta1, GSTCD, GSTO2, GSTT2B, GSTT4, HES1, HIF-1 alpha, HSV-1 gG, ISGF-3γ p48, LOXL1, Measles NP, Myosin-XVA, Myt 1, Naglt1c, NK 2B4, Nucling, OATP-C, OATP-D, OATP-E, OATP-F, OATP16, OATP2A1, OATP8, Oct-3/4, Pit-1, PSP94, RAO, RARα1, Retnlb, RFT1, RORα, Septin 5, SGLT-3, SKN-1, SLC43A1, Sp1, Spot 14, Sulfotransferase (SULT1), SULT1A2, SULT1C1, SULT1C3, SULT2A5, SULT2B1, SULT2B10, TBC1D9B, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A6B, UGT1A7, UGT1A9, UGT2A1, UGT2A2, UGT2B1, UGT2B11, UGT2B37, UGT2B38, UGT2B4, UGT2B5, UGT3A2, V1RC24, V1RF5, Vaspin, Xlr4a, Xlr4c, Xlr5a, Xlr5b, Xlr5c, ZNF737, and ZSCAN4F.Activator of:
17-β Estradiol, 17β-HSD, Abcg3, CES7, CRB3, creatine kinase-M, Cyp2c66, CYP4V3, CYP4Z1, Dlx-5, DNAH2, DNAH3, FSH, gp100, H2-Q10, LOC100041253, MRP2, MRP3, MUP16, Nrf3, OAT6, OATP-A, Oatp-Y, OCT1, Pax-2, Progesterone, PUMA, RAP, S100A7A, SLC22A9, Slco6c1, Slco6d1, SMR2, SPOP, SULT1A3, SULT1A4, SULT1B1, SULT2A2, SULT2A7, UGT1A1, UGT1A2, UGT1A5, UGT1A6A, UGT1A6B, UGT1A8, UGT2A2, UGT2A3, UGT2B10, UGT2B11, UGT2B28, UGT2B35, UGT2B36, UGT2B37, UGT2B4, UGT3A1, UGT3A2, Vmn1r129, XAP2, and Zearalenone.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chrysin, 1 g | sc-204686 | 1 g | $38.00 |