CDw75/ST6GAL1 Antibody (B-L5): sc-65306

ST6GAL1 Antibody (B-L5) is a mouse monoclonal IgM antibody that detects ST6GAL1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). ST6GAL1, also known as CD75, is a crucial sialyltransferase that plays a significant role in modifying cell surface glycoproteins and glycolipids, which is essential for various cellular processes, including tumorigenesis and metastasis. This enzyme catalyzes sialic acid transfer into carbohydrate chains on glycoproteins, facilitating the generation of sialylated antigens that serve as important cell-surface carbohydrate determinants. ST6GAL1 is primarily expressed in the Golgi apparatus and secreted into the extracellular fluid, where ST6GAL1 contributes to the formation of specific antigens such as CDw75, predominantly found on B and T cells. CDw75 has been linked to upregulation in B-cell leukemias, indicating a potential role in carcinogenesis and highlighting ST6GAL1′s importance in immune response and cancer biology. Anti-ST6GAL1 antibody (B-L5) serves as an invaluable tool for researchers investigating the functional implications of ST6GAL1 in health and disease.

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CDw75/ST6GAL1 Antibody (B-L5) References:

1. Cell cycle-dependent regulation of CDw75 (beta-galactoside alpha-2,6-sialyltransferase) on human B lymphocytes.  |  Erikstein, BK., et al. 1992. Eur J Immunol. 22: 1149-55. PMID: 1577059
2. Characteristics of two CD75-related cell-surface expressed antigens of human lymphocytes.  |  Eichler, W. 2007. Mol Immunol. 44: 2047-55. PMID: 17067678
3. The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.  |  Stamenkovic, I., et al. 1991. Cell. 66: 1133-44. PMID: 1717156
4. The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase.  |  Bast, BJ., et al. 1992. J Cell Biol. 116: 423-35. PMID: 1730763
5. St6gal1 knockdown alters HBV life cycle in HepAD38 cells.  |  Priyambada, SA., et al. 2018. Biochem Biophys Res Commun. 503: 1841-1847. PMID: 30057317
6. ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab.  |  Duarte, HO., et al. 2021. Oncogene. 40: 3719-3733. PMID: 33947960
7. Glycomics reveal that ST6GAL1-mediated sialylation regulates uterine lumen closure during implantation.  |  Han, K., et al. 2022. Cell Prolif. 55: e13169. PMID: 34957619
8. Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential.  |  Epstein, AL., et al. 1987. Cancer Res. 47: 830-40. PMID: 3542194
9. Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.  |  Zhou, Y., et al. 2024. Clin Neuropathol. 43: 113-126. PMID: 39120072
10. CDw75 antigen expression in breast lesions.  |  Reed, W., et al. 1993. Pathol Res Pract. 189: 394-8. PMID: 7688897
11. CDw75 antigen expression in human gastric carcinoma and adjacent mucosa.  |  David, L., et al. 1993. Cancer. 72: 1522-7. PMID: 8348485
12. HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens.  |  De Lau, WB., et al. 1993. J Immunol. 150: 4911-9. PMID: 8496593

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDw75/ST6GAL1 Antibody (B-L5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CDw75/ST6GAL1 Antibody (B-L5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDw75/ST6GAL1 Antibody (B-L5) Specifications

Alternate Product Name: CD75

Product Clone Name: B-L5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: CD75

Epitope Species: human

Product Reactivity/Detection: CD75

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CDw75/ST6GAL1 Antibody (B-L5): N/A

The preferred CDw75/ST6GAL1 antibody is CDw75/ST6GAL1 Antibody (LN-1): sc-6263.