BTEB2 Antibody (B-8): sc-398409

BTEB2 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects BTEB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BTEB2, a member of the C2H2 zinc finger family, plays a crucial role in gene regulation by binding to GC-rich motifs found in gene promoters, which can lead to either the activation or repression of transcriptional activities. BTEB2 (B-8) antibody is particularly valuable for studying vascular smooth muscle cell modulation in response to mitogen stimulation, a process critical for vascular remodeling following injury. BTEB2 is expressed in the fetal aorta and interacts with early growth response protein 1 (Egr-1), which serves as a target for regulatory functions. BTEB2 activation occurs through mitogen-activated protein kinase pathways, highlighting its significance in cellular responses to external stimuli. BTEB2 monoclonal antibody (B-8) serves as an essential tool for researchers studying vascular diseases, given BTEB2′s influence on gene expression in vascular smooth muscle cells and potential as a therapeutic target.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BTEB2 Antibody (B-8) References:

1. BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene.  |  Watanabe, N., et al. 1999. Circ Res. 85: 182-91. PMID: 10417400
2. Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells.  |  Kawai-Kowase, K., et al. 1999. Circ Res. 85: 787-95. PMID: 10532946
3. Inducible expression of basic transcription element-binding protein 2 in proliferating smooth muscle cells at the vascular anastomotic stricture.  |  Ogata, T., et al. 2000. J Thorac Cardiovasc Surg. 119: 983-9. PMID: 10788819
4. Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling.  |  Wada, Y., et al. 2000. Transplant Proc. 32: 1089-91. PMID: 10936371
5. Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis.  |  Hoshino, Y., et al. 2000. Circulation. 102: 2528-34. PMID: 11076828
6. Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis.  |  Chaib, H., et al. 2001. Neoplasia. 3: 43-52. PMID: 11326315
7. Gene structure and promoter analysis of the rat BTEB2 gene.  |  Mori, D., et al. 2003. Gene. 304: 163-70. PMID: 12568725
8. Significance of the transcription factor KLF5 in cardiovascular remodeling.  |  Nagai, R., et al. 2005. J Thromb Haemost. 3: 1569-76. PMID: 16102021
9. A survey of well conserved families of C2H2 zinc-finger genes in Daphnia.  |  Seetharam, A., et al. 2010. BMC Genomics. 11: 276. PMID: 20433734
10. BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model.  |  Li, D., et al. 2011. Mol Med Rep. 4: 413-7. PMID: 21468585

The preferred BTEB2 antibody is BTEB2 Antibody (G-7): sc-398470.