BMAL1 Antibody (B-1): sc-365645

BMAL1 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BMAL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMAL1 (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMAL1 protein, also known as brain and muscle Arnt-like protein 1, plays a crucial role in circadian rhythm regulation by forming a heterodimer with Clock protein, which then binds to promoter regions of target genes such as mPer1. This interaction maintains the body′s internal clock, influencing physiological processes including sleep-wake cycles, hormone release, and metabolism. Disruptions in BMAL1 function can lead to circadian rhythm disorders and have been linked to metabolic syndromes and other health issues. Additionally, BMAL1 belongs to a larger family of transcription factors including aromatic hydrocarbon receptor (AhR) and nuclear translocator proteins (Arnt 1 and Arnt 2), which are essential for ligand-dependent activation of genes involved in detoxification processes. anti-BMAL1 antibody (B-1) versatility in various applications makes this product an invaluable tool for researchers studying circadian biology and its implications in health and disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BMAL1 Antibody (B-1) References:

1. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.  |  Reyes, H., et al. 1992. Science. 256: 1193-5. PMID: 1317062
2. Circadian rhythms in the absence of the clock gene Bmal1.  |  Ray, S., et al. 2020. Science. 367: 800-806. PMID: 32054765
3. BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress.  |  Xie, M., et al. 2020. Circ Res. 126: e15-e29. PMID: 32078488
4. An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.  |  Sheehan, PW., et al. 2023. Neuron. 111: 2383-2398.e7. PMID: 37315555
5. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca2+ overload.  |  Zhang, N., et al. 2023. Redox Biol. 64: 102788. PMID: 37356134
6. BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep.  |  Rojo, D., et al. 2023. Neuron. 111: 3604-3618.e11. PMID: 37657440
7. Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator.  |  Sogawa, K., et al. 1995. J Cancer Res Clin Oncol. 121: 612-20. PMID: 7559746
8. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).  |  Hirose, K., et al. 1996. Mol Cell Biol. 16: 1706-13. PMID: 8657146
9. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT).  |  Drutel, G., et al. 1996. Biochem Biophys Res Commun. 225: 333-9. PMID: 8753765
10. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.  |  Ikeda, M. and Nomura, M. 1997. Biochem Biophys Res Commun. 233: 258-64. PMID: 9144434
11. Ah receptor, a novel ligand-activated transcription factor.  |  Sogawa, K. and Fujii-Kuriyama, Y. 1997. J Biochem. 122: 1075-9. PMID: 9498548
12. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus.  |  Honma, S., et al. 1998. Biochem Biophys Res Commun. 250: 83-7. PMID: 9735336

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMAL1 Antibody (B-1) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-BMAL1 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMAL1 Antibody (B-1) Specifications

Alternate Product Name: BMAL1

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 441-610

Epitope Target: BMAL1

Epitope Species: human

Product Reactivity/Detection: BMAL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for BMAL1 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent