ATRA-BA Hybrid is the combination of a differentiation-inducer all-trans-Retinoic Acid and the HDAC inhibitor Butyric Acid that have been incorporated chemically via a benzyl ester linkage into a single more permeant mutual prodrug (MP) to help their cellular uptake and to better synergize their cancer killing efficiency.
Gediya, L.K., et al. 2008. J. Med. Chem. 51, 3895. R: 22-36/37/38-63; S: 22-26-36-45
Estado de Materia
Soluble in DMSO (5 mg/ml), and ethanol.
Store at -20° C
Punto de ebullición
597.04° C at 760 mmHg (Predicted)
1.05 g/cm3 (Predicted)
Indice de Refracción
n20D 1.55 (Predicted)
PC-3: IC50 = 1.02 µM; MDA-MB-231 : IC50 = 0.01 µM
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
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