ASB-10 Antibody (QQ6): sc-100677

ASB-10 Antibody (QQ6) is a mouse monoclonal IgG2a kappa light chain antibody that detects ASB-10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ASB-10 (QQ6) antibody is available as a non-conjugated anti-ASB-10 antibody, providing researchers with a reliable tool for studying this important protein. ASB-10 is a member of the ankyrin repeat and SOCS box-containing (ASB) protein family, which plays a crucial role in various biological processes, including the regulation of cytokine signaling. ASB-10 consists of 467 amino acids and features seven ankyrin repeats along with a SOCS box domain, which is essential for interaction with the Elongin B and C complex. Notably, ASB-10 contains a unique LS sequence in the conserved BC box subdomain of the SOCS box, differing from the common LC sequence found in other SOCS proteins; however, this alteration does not appear to disrupt protein interactions. The presence of two isoforms due to alternative splicing further highlights the complexity and functional diversity of ASB-10, making ASB-10 a significant subject of study in understanding the mechanisms of cytokine signaling and its implications in various diseases.

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ASB-10 Antibody (QQ6) References:

1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.  |  Kile, BT., et al. 2000. Gene. 258: 31-41. PMID: 11111040
2. The SOCS box: a tale of destruction and degradation.  |  Kile, BT., et al. 2002. Trends Biochem Sci. 27: 235-41. PMID: 12076535
3. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.  |  Kohroki, J., et al. 2005. FEBS Lett. 579: 6796-802. PMID: 16325183
4. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.  |  Debrincat, MA., et al. 2007. J Biol Chem. 282: 4728-4737. PMID: 17148442
5. Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?  |  Bork, P. 1993. Proteins. 17: 363-74. PMID: 8108379
6. Twenty proteins containing a C-terminal SOCS box form five structural classes.  |  Hilton, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 114-9. PMID: 9419338