ARG1/Arginase 1 Antibody (8C9): sc-47715

Arginase 1 Antibody (8C9) is a mouse monoclonal IgG1 antibody designed to detect both Arginase 1 and Arginase 2 across mouse, rat, and human species using western blotting (WB) and immunoprecipitation (IP) techniques. Arginase 1 monoclonal antibody (8C9) is raised against recombinant human type I arginase, ensuring robust binding to the target protein. Arginase 1, also called ARG1, AI, Arg-1, and PGIF, is a crucial enzyme primarily expressed in the liver, where Arginase 1 plays a vital role in the urea cycle by catalyzing the hydrolysis of arginine into ornithine and urea, thereby facilitating the removal of excess nitrogen from the body. Structurally, Arginase 1 functions as a homotrimeric protein and contains a binuclear manganese cluster essential for enzymatic activity. Understanding Arginase 1 function is important as Arginase 1 not only regulates amino acid metabolism but also influences various physiological and pathological processes, including wound healing, immune response, and cancer progression. Additionally, Arginase 2, which shares the same catalytic activity but differs in tissue distribution and subcellular localization, is predominantly found in the mitochondria of non-hepatic tissues such as the kidneys. Anti-Arginase 1 antibody (8C9) detection of both isoforms across multiple species makes this antibody an invaluable tool for researchers studying metabolic pathways, enzyme regulation, and disease mechanisms related to arginine metabolism.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARG1/Arginase 1 Antibody (8C9) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-ARG1/Arginase 1 Antibody (8C9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARG1/Arginase 1 Antibody (8C9) Specifications

Alternate Product Name: Arginase 1

Product Clone Name: 8C9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Arginase 1

Epitope Species: human

Product Reactivity/Detection: Arginase 1 and Arg2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for ARG1/Arginase 1 Antibody (8C9): N/A

The preferred ARG1/Arginase 1 antibody is ARG1/Arginase 1 Antibody (C-2): sc-166920.