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5-Methyltetrahydrofolic acid disodium salt (CAS 68792-52-9)

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Alternate Names:
5-Methyltetrahydrofolic acid disodium salt is also known as 5-Methyl-THF.
Application:
5-Methyltetrahydrofolic acid disodium salt is a substrate and a cofactor used for regenerating methionine from homocysteine.
CAS Number:
68792-52-9
Purity:
≥88%
Molecular Weight:
503.42
Molecular Formula:
C20H23N7O62Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Methyltetrahydrofolic acid disodium salt is a compound that plays a pivotal role in the research of one-carbon metabolism and its associated biochemical pathways. In nutritional biochemistry, it is utilized to study the methylation cycle, which is vital for DNA synthesis and repair, as well as for the regulation of gene expression. This compound is also a subject of interest in the context of enzymology, where researchers investigate its role as a cofactor for various enzymes involved in the transfer of methyl groups. In studies of folate metabolism, 5-Methyltetrahydrofolic acid disodium salt is used to explore the interconversion of folate derivatives and their physiological implications. Its stability as a salt form facilitates its use in various analytical techniques aimed at quantifying folate levels in biological samples. Research utilizing 5-Methyltetrahydrofolic acid disodium salt contributes to a deeper understanding of cellular function and nutritional sciences.


5-Methyltetrahydrofolic acid disodium salt (CAS 68792-52-9) References

  1. Preliminary application of liquid chromatography-electrospray-ionization mass spectrometry to the detection of 5-methyltetrahydrofolic acid monoglutamate in human plasma.  |  Nelson, BC., et al. 2001. J Chromatogr B Biomed Sci Appl. 765: 141-50. PMID: 11767307
  2. Photodegradation of folic acid during extracorporeal photopheresis.  |  Der-Petrossian, M., et al. 2007. Br J Dermatol. 156: 117-21. PMID: 17199577
  3. pH-Dependent radical scavenging activity of folates.  |  Gliszczyńska-Swigło, A. and Muzolf, M. 2007. J Agric Food Chem. 55: 8237-42. PMID: 17848080
  4. Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions.  |  Keating, E., et al. 2009. Reprod Toxicol. 28: 511-20. PMID: 19616087
  5. Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells.  |  Araújo, JR., et al. 2010. Biofactors. 36: 201-9. PMID: 20232349
  6. Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death.  |  Hemendinger, RA., et al. 2011. Toxicol Appl Pharmacol. 251: 217-25. PMID: 21237187
  7. The effect of oxidative stress upon the intestinal uptake of folic acid: in vitro studies with Caco-2 cells.  |  Couto, MR., et al. 2012. Cell Biol Toxicol. 28: 369-81. PMID: 22956110
  8. The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality.  |  Alvarez-Suarez, JM., et al. 2017. Food Funct. 8: 3250-3258. PMID: 28815233
  9. Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress.  |  Alvarez-Suarez, JM., et al. 2018. Plant Foods Hum Nutr. 73: 18-24. PMID: 29455277
  10. Comparison of ESI-MS/MS and APCI-MS methods for the quantification of folic acid analogs in C. elegans.  |  Annibal, A., et al. 2019. J Mass Spectrom. 54: 316-327. PMID: 30675959
  11. Biological Activity of Pseudovitamin B12 on Cobalamin-Dependent Methylmalonyl-CoA Mutase and Methionine Synthase in Mammalian Cultured COS-7 Cells.  |  Bito, T., et al. 2020. Molecules. 25: PMID: 32709013
  12. Folic acid supplementation rescues valproic acid-induced developmental neurotoxicity and behavioral alterations in zebrafish embryos.  |  Muhsen, M., et al. 2021. Epilepsia. 62: 1689-1700. PMID: 33997963
  13. Thiol redox modulation of tumor necrosis factor-alpha responsiveness in cultured AIDS-related Kaposi's sarcoma cells.  |  Mallery, SR., et al. 1998. J Cell Biochem. 68: 339-54. PMID: 9518260

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Methyltetrahydrofolic acid disodium salt, 5 mg

sc-214334
5 mg
$141.00

5-Methyltetrahydrofolic acid disodium salt, 10 mg

sc-214334A
10 mg
$228.00

5-Methyltetrahydrofolic acid disodium salt, 25 mg

sc-214334B
25 mg
$485.00

5-Methyltetrahydrofolic acid disodium salt, 50 mg

sc-214334C
50 mg
$583.00

5-Methyltetrahydrofolic acid disodium salt, 100 mg

sc-214334D
100 mg
$1165.00

5-Methyltetrahydrofolic acid disodium salt, 200 mg

sc-214334E
200 mg
$1883.00

How is this chemical packaged? Glass ampoules, plastic bottle with cap, other?

Asked by: jackieo5367
Thank you for your question. This can be lot dependent, but the most current lot is provided in a glass vial.
Answered by: Tech Service
Date published: 2019-03-29
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Rated 5 out of 5 by from Rodriguez JM; et alRodriguez JM; et al. (PubMed ID: 25802929) determined that 5-Methyltetrahydrofolic acid disodium salt increased cell growth in HT29 cells via the Notch1 pathway. -SCBT Publication Review
Date published: 2015-04-27
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5-Methyltetrahydrofolic acid disodium salt is rated 5.0 out of 5 by 1.
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