2prime-Thioadenosine CAS: 60239-18-1 (non-salt)
MF: C10H13N5O3S
MW: 283.3
A potent, selective inhibitor of ErbB1/ErbB2.

2′-Thioadenosine (CAS 60239-18-1 (non-salt))

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Solicitud: 2′-Thioadenosine is a potent, selective inhibitor of ErbB1/ErbB2
Número de CAS: 60239-18-1 (non-salt)
Peso Molecular: 283.3
Fórmula Molecular: C10H13N5O3S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
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2'-Thioadenosine is a potent, selective, and irreversible inhibitor of the catalytic domain of the ErbB subfamily of protein tyrosine kinases. 2'-Thioadenosine inactivates epidermal growth factor receptor (ErbB1) via modification of a cysteine residue at the active site. This inactivation is reversed with the addition of 1mM dithiothreitol (DTT). 2'-Thioadenosine has also been shown to inhibit Neu/Her2 growth factor receptor (ErbB2, IC50 = 45 µM).


References

1. Singh, J., et al., 1997. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. Journal of medicinal chemistry. 40(7): 1130-5. PMID: 9089334

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO or Water
ALMACENAMIENTO :
Store at -20° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
SMILES :

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