1-Naphthohydroxamic Acid is a selective and potent HDAC8 inhibitor with a measured IC50 equivalent to 14 μM. 1-Naphthohydroxamic Acid also displays a IC50 >100 μM for class I HDAC1 and class II HDAC6. In contrast to pan-HDAC inhibitors, the compound does not reduce total intracellular HDAC activity.
1. Krennhrubec, Keris., Marshall, Brett L., Hedglin, Mark., Verdin, Eric., Ulrich, Scott M., 2007. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorganic & medicinal chemistry letters. 17(10): 2874-8. PMID: 17346959
Estado de Materia
Soluble in DMSO (50 mg/mL), and methanol (almost transparency).
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