1-Naphthohydroxamic Acid CAS: 6953-61-3
MF: C11H9NO2
MW: 187.19
A potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.

1-Naphthohydroxamic Acid (CAS 6953-61-3)

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Nombres Alternativos: N-Hydroxynaphthalene-1-carboxamide; a-Naphthohydroxamic acid
Solicitud: 1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6
Número de CAS: 6953-61-3
Peso Molecular: 187.19
Fórmula Molecular: C11H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

1-Naphthohydroxamic Acid is a selective and potent HDAC8 inhibitor with a measured IC50 equivalent to 14 μM. 1-Naphthohydroxamic Acid also displays a IC50 >100 μM for class I HDAC1 and class II HDAC6. In contrast to pan-HDAC inhibitors, the compound does not reduce total intracellular HDAC activity.


References

1. Krennhrubec, Keris., Marshall, Brett L., Hedglin, Mark., Verdin, Eric., Ulrich, Scott M., 2007. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorganic & medicinal chemistry letters. 17(10): 2874-8. PMID: 17346959

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (50 mg/mL), and methanol (almost transparency).
ALMACENAMIENTO :
Store at 4° C
Punto de Fusión :
161.31° C (Predicted)
Punto de ebullición :
417.22° C (Predicted)
Densidad :
1.29 g/cm3
Indice de Refracción :
n20D 1.68
IC50 :
Plasmodium falciparum M17 Leucine Aminopeptidase: IC50 = 9.08 µM; HDAC8: IC50 = 14 µM; Arachidonate 5-lipoxygenase: IC50 = 42.66 µM (rat); MMP-3: IC50 = 50 µM (human); HDAC6: IC50 = > 100 µM
Valores de pK :
pKa: 8.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Alemania :
3
RTECS :
QJ1894500
PubChem CID :
23382
Número MDL :
MFCD00059546
Registro Beilstein :
2094470
SMILES :
C1=CC=C2C(=C1)C=CC=C2C(=O)NO

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

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