1,2-Dioctanoyl-sn-glycerol CAS: 60514-48-9
MF: C19H36O5
MW: 344.49

1,2-Dioctanoyl-sn-glycerol (CAS 60514-48-9)

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1,2-Dioctanoyl-sn-glycerol is rated 5.0 out of 5 by 1.
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Nombres Alternativos: 1,2-Dioctanoyl-sn-glycerol is also known as 1,2-bis(O-octanoyl)-sn-glycerol.
Solicitud: 1,2-Dioctanoyl-sn-glycerol is a cell-permeable analog of diacylglycerol and activator of protein kinase C (PKC).
Número de CAS: 60514-48-9
Pureza: ≥95%
Peso Molecular: 344.49
Fórmula Molecular: C19H36O5
Información suplementaria: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
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1,2-Dioctanoyl-sn-glycerol is a cell-permeable activator of protein kinase C (PKC). 1,2-Dioctanoyl-sn-glycerol exhibits lower affinity for PKCa than for other isozymes. 1,2-Dioctanoyl-sn-glycerol is shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells. 1,2-Dioctanoyl-sn-glycerol is an analog of the lipid second messenger diacylglycerol (DAG).


References

1. Doherty, C.M., Tarchala, S.M., Radwanska, E., et al.Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. Journal of Andrology 16, 36-46 (1995).
2. Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
3. MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
4. Davis, R.J. 1985. J. Biol. Chem. 260, 1562.

Formulación :
A solution in acetonitrile
Estado de Materia :
Liquid
Solubilidad :
Soluble in DMSO (7 mg/ml), chloroform, 100% ethanol, dichloromethane, ether, ethyl acetate, methanol, most organic solvents, DMF (7 mg/ml), PBS (pH 7.2) (250 ug/ml), water (>250 ug/ml at 25° C), and cyclohexane.
ALMACENAMIENTO :
Store at -80° C
Punto de ebullición :
81-82° C
Indice de Refracción :
n20D 1.46 (Predicted)
IC50 :
Protein kinase C alpha: IC50 = 5 µM (mouse); Protein kinase C delta: IC50 = 5 µM (mouse); Protein kinase C gamma: IC50 = 5 µM (mouse); Protein kinase C eta: IC50 = 5 µM (mouse); Protein kinase C beta: IC50 = 5 µM (mouse)
Datos Ki :
Protein kinase C alpha: Ki= 33 nM (human)
Valores de pK :
pKa: 13.70 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
RH0764500
PubChem CID :
Número MDL :
MFCD00036835
Registro Beilstein :
1714754
SMILES :
CCCCCCCC(=O)OC[[email protected]](CO)OC(=O)CCCCCCC

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PMID: # 33478104  Loke, ASW.|Longley, BJ.|Lambert, PF.|Spurgeon, ME.| et al. 2021. Viruses. 13:

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