ZNF143 Antibody (L-26): sc-100983

ZNF143 Antibody (L-26) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZNF143 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ZNF143 antibody (L-26) is available as the non-conjugated format. ZNF143, also known as zinc finger protein 143, SBF, STAF, or pHZ-1, is a 626 amino acid protein characterized by seven C2H2-type zinc fingers, which are crucial for function as a transcriptional activator. ZNF143 is predominantly localized in the nucleus and exhibits ubiquitous expression, with highest levels found in the ovaries. ZNF143 binding to the SPH motif in promoters of small nuclear RNAs (snRNA) underscores a significant role in regulating expression of genes involved in RNA processing and transcriptional control. ZNF143 expression is upregulated in response to DNA damage, highlighting an essential function in DNA repair mechanisms, which is critical for maintaining genomic stability and cellular integrity.

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ZNF143 Antibody (L-26) References:

1. Complex regulation of human neuronal nitric-oxide synthase exon 1c gene transcription. Essential role of Sp and ZNF family members of transcription factors.  |  Saur, D., et al. 2002. J Biol Chem. 277: 25798-814. PMID: 11960979
2. ZNF143 mediates basal and tissue-specific expression of human transaldolase.  |  Grossman, CE., et al. 2004. J Biol Chem. 279: 12190-205. PMID: 14702349
3. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA.  |  Ishiguchi, H., et al. 2004. Int J Cancer. 111: 900-9. PMID: 15300802
4. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters.  |  Myslinski, E., et al. 2006. J Biol Chem. 281: 39953-62. PMID: 17092945
5. ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes.  |  Wakasugi, T., et al. 2007. Oncogene. 26: 5194-203. PMID: 17297437
6. Transcription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143.  |  Myslinski, E., et al. 2007. Nucleic Acids Res. 35: 3453-64. PMID: 17478512
7. Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene.  |  Gérard, MA., et al. 2007. Gene. 401: 145-53. PMID: 17707600
8. ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf.  |  Myslinski, E., et al. 1998. J Biol Chem. 273: 21998-2006. PMID: 9705341
9. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter.  |  Rincon, JC., et al. 1998. Nucleic Acids Res. 26: 4846-52. PMID: 9776743

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF143 Antibody (L-26) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF143 Antibody (L-26) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF143 Antibody (L-26) Specifications

Alternate Product Name: ZNF143

Product Clone Name: L-26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-627

Epitope Target: ZNF143

Epitope Species: human

Product Reactivity/Detection: ZNF143

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for ZNF143 Antibody (L-26): N/A