Molecular structure of VU 0155041
VU 0155041
Alternate Names:
(±)-cis-2-(3,5-Dicholorphenylcarbamoyl)cyclohexanecarboxylic acid
Application:
VU 0155041 is a positive allosteric modulator/agonist at mGluR-4
Molecular Weight:
316.18
Molecular Formula:
C14H15Cl2NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). In vivo models of Parkinson′s disease, active following i.c.v. administration.
VU 0155041 References
- Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. | Duvoisin, RM., et al. 2011. Behav Brain Res. 221: 50-4. PMID: 21382421
- Measures of anxiety, sensorimotor function, and memory in male and female mGluR4⁻/⁻ mice. | Davis, MJ., et al. 2012. Behav Brain Res. 229: 21-8. PMID: 22227508
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. | Volpi, C., et al. 2018. Expert Opin Drug Discov. 13: 411-423. PMID: 29486616
- A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System. | Farkas, E., et al. 2020. iScience. 23: 100921. PMID: 32143135
- Chronic activation of muscarinic and metabotropic glutamate receptors down-regulates type I inositol 1,4,5-trisphosphate receptor expression in cerebellar granule cells. | Simpson, PB., et al. 1994. J Neurochem. 63: 2369-72. PMID: 7964761
Activator of:
mGluR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 0155041, 10 mg | sc-204385 | 10 mg | $49.00 | |||
VU 0155041, 50 mg | sc-204385A | 50 mg | $155.00 |