uPA/urokinase/PLAU Antibody (PGM2001): sc-59728
- uPA/urokinase/PLAU Antibody (PGM2001) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against uPA of human origin
- recommended for detection of uPA of human origin by WB and IF; non cross-reactive with other serine proteases
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for uPA/urokinase/PLAU Antibody (PGM2001). This work is in progress.
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SEE ALSO...
uPA Antibody (PGM2001) is a mouse monoclonal IgG1 antibody raised against human urokinase-type plasminogen activator (uPA), also known as PLAU or urokinase. Anti-uPA antibody (PGM2001) specifically detects uPA of human origin by western blotting (WB) and immunofluorescence (IF) without cross-reactivity to other serine proteases. uPA is a serine protease composed of two chains, A and B, connected by a disulfide bond, and features essential structural domains such as the kringle domain and the serine protease domain. The kringle domain facilitates protein-protein interactions and binding to the urokinase receptor (uPAR), while the serine protease domain is responsible for converting plasminogen to plasmin, a key step in fibrinolysis. The structural configuration of uPA allows precise regulation of proteolytic activity on the cell surface, influencing processes like cell migration, tissue remodeling, and wound healing. Dysregulation of uPA′s structure and function has been implicated in pathological conditions, including cancer metastasis, making uPA a significant focus in biomedical research. uPA monoclonal antibody (PGM2001) serves as a valuable tool for studying uPA′s role in physiological and pathological processes, aiding in the development of therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
uPA/urokinase/PLAU Antibody (PGM2001) | sc-59728 | 100 µg/ml | $322.00 |