Ubiquitin Aldehyde
Ubiquitin Aldehyde has shown to inhibit the activity of USP5 and UCH-L1. It is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. It inhibits deubiquitinylating enzyme activity and can be used to identify such activity to determine the inhibition kinetics for a particular enzyme. Ubiquitin Aldehyde is a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including UCHs (ubiquitin C-terminal hydrolases), USPs (ubiquitin-specific proteases) and DUBs (deubiquitinylating enzymes). Concentration recommended for maximal inhibition is 2-5μM.
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Ubiquitin Aldehyde Publikationen
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PMID: # 30532073 Liu, B. et al. 2018. Oncogene.
PMID: # 30340022 Wan, W. et al. 2018. Mol. Cell. 72: 303-315.e6.
PMID: # 28672898 Geng, Z.|Wei, L.|Zhang, C.|Yan, X.| et al. 2017. Exp Ther Med. 14: 91-96.
PMID: # 28775317 Sun, W. et al. 2017. Sci Rep. 7: 7190.
PMID: # 29084198 Hein, JB. et al. 2017. Nat. Cell Biol. 19: 1433-1440.
PMID: # 22163316 Ferrero, M. et al. 2011. PLoS ONE. 6: e28602.
PMID: # 19244336 Whitehurst, CB.|Ning, S.|Bentz, GL.|Dufour, F.|Gershburg, E.|Shackelford, J.|Langelier, Y.|Pagano, JS.| et al. 2009. J Virol. 83: 4345-53.
PMID: # 16211010 Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y. et al. 2005. EMBO J. 24: 3747-3756.
PMID: # 14559776 Burnett, B. et al. 2003. Hum. Mol. Genet. 12: 3195-3205.
PMID: # 14663138 Shackelford, J. et al. 2003. Proc. Natl. Acad. Sci. USA. 100: 15572-6.