TRP1 Antibody (3F388): sc-58437

TRP1 Antibody (3F388) is a mouse monoclonal IgG2a antibody that detects TRP1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, functioning as a melanogenic enzyme that contributes to the production of eumelanin and pheomelanin, the two primary types of melanin found in vertebrates. TRP1 is predominantly located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the complex process of melanin production. Proper localization of TRP1 within the melanosomal membrane is essential for enzymatic activity and stability, as such positioning ensures optimal interaction with substrates and other proteins involved in melanin synthesis. Deficiencies or mutations in TRP1 can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal skin and hair color. Anti-TRP1 antibody (3F388) serves as an invaluable tool for researchers studying pigmentation, melanin biosynthesis, and related genetic conditions, providing reliable detection and characterization of TRP1 in various biological samples.

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TRP1 Antibody (3F388) References:

1. Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells.  |  Liu, X., et al. 2000. J Biol Chem. 275: 3403-11. PMID: 10652333
2. Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.  |  Lintschinger, B., et al. 2000. J Biol Chem. 275: 27799-805. PMID: 10882720
3. Cloning and sequencing analysis of Trp1 gene of Flammulina velutipes.  |  Nakai, R., et al. 2000. FEMS Microbiol Lett. 190: 51-6. PMID: 10981689
4. Construction of an Arxula adeninivorans host-vector system based on trp1 complementation.  |  Steinborn, G., et al. 2007. J Biotechnol. 127: 392-401. PMID: 16934902
5. TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes.  |  Kedlaya, RH., et al. 2006. Arch Biochem Biophys. 454: 160-9. PMID: 16962991
6. Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes.  |  Kedlaya, R., et al. 2011. Arch Biochem Biophys. 508: 227-33. PMID: 21291857
7. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse.  |  Thanos, A., et al. 2012. Am J Pathol. 180: 1917-27. PMID: 22429967
8. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.  |  Dougan, SK., et al. 2013. Cancer Immunol Res. 1: 99-111. PMID: 24459675
9. In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1).  |  Chen, JM., et al. 2024. Am J Dermatopathol. 46: 563-571. PMID: 39008470
10. Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation.  |  Ostrander, DB. and Gorman, JA. 1994. Gene. 148: 179-85. PMID: 7958943

The preferred TRP1 antibody is TRP1 Antibody (TA99): sc-58438.