Troponin T-C Antibody (1F2): sc-52284
- Troponin T-C Antibody (1F2) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against full length cardiac Troponin T of bovine origin, with epitope mapping to amino acids 60-70
- recommended for detection of cardiac muscle Troponin T of human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and bovine, feline and canine
- See Troponin T-C (CT3): sc-20025 for Troponin T-C antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Troponin T-C Antibody (1F2). This work is in progress.
QUICK LINKS
SEE ALSO...
Troponin T-C Antibody (1F2) is a mouse monoclonal IgG1 antibody that detects Troponin T in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Troponin T plays a critical role in the regulation of muscle contraction by serving as a link between the troponin complex and actin filaments in muscle cells. Anti-Troponin T antibody (1F2) helps researchers study this protein′s essential function in cardiac and skeletal muscles, where Troponin T modulates the interaction between actin and myosin in response to calcium levels. The structure of Troponin T contains specific domains that bind to tropomyosin, stabilizing the thin filament and facilitating the contraction process. Different Troponin T isoforms are expressed in various muscle types, allowing for specialized functions in cardiac and skeletal muscle physiology. Post-translational modifications, such as phosphorylation, influence Troponin T′s interaction with other proteins and role in muscle contraction, making Troponin T monoclonal antibody (1F2) an invaluable tool for research in muscle-related diseases and cardiac function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Troponin T-C Antibody (1F2) References:
- Cardiac troponin-T in acute pericarditis. | Gamaza-Chulián, S., et al. 2014. J Cardiovasc Med (Hagerstown). 15: 68-72. PMID: 23846679
- Clearance of cardiac troponin T with and without kidney function. | Fridén, V., et al. 2017. Clin Biochem. 50: 468-474. PMID: 28193484
- Elevated Cardiac Troponin T in Patients With Skeletal Myopathies. | Schmid, J., et al. 2018. J Am Coll Cardiol. 71: 1540-1549. PMID: 29622161
- Cardiac Troponin T in Healthy Full-Term Infants. | Karlén, J., et al. 2019. Pediatr Cardiol. 40: 1645-1654. PMID: 31489446
- Applying High-Sensitivity Cardiac Troponin T. | Glarner, N., et al. 2021. J Am Coll Cardiol. 78: e147. PMID: 34711344
- Cardiac troponin T and autoimmunity in skeletal muscle aging. | Zhang, T., et al. 2022. Geroscience. 44: 2025-2045. PMID: 35034279
- Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T. | du Fay de Lavallaz, J., et al. 2022. Circulation. 145: 1764-1779. PMID: 35389756
- Cardiac troponin T as a postmortem biomarker for acute myocardial infarction. | Moridi, M., et al. 2022. Forensic Sci Int. 341: 111506. PMID: 36368163
- Smartphone-based colorimetric detection of cardiac troponin T via label-free aptasensing. | Ulloa-Gomez, AM., et al. 2023. Biosens Bioelectron. 222: 114938. PMID: 36462432
- Commentary on Resolved Myositis, Normal CPK, and Peaking Cardiac Troponin T. | Christenson, RH. 2024. J Appl Lab Med. 9: 853-854. PMID: 38712710
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Troponin T-C Antibody (1F2) | sc-52284 | 100 µg/ml | $322.00 |