TNF-R1 Antibody (G-2): sc-374185

TNF-R1 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects tumor necrosis factor receptor 1 (TNF-R1) in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TNF-R1 plays a crucial role in mediating the effects of tumor necrosis factor, a key cytokine involved in systemic inflammation and immune responses. TNF-R1 is predominantly located on the surface of most cell types, allowing TNF-R1 to initiate a wide range of cellular responses, including apoptosis, cell survival, and inflammation. TNF-R1′s ability to transduce signals that lead to apoptosis is particularly important in regulating immune responses and maintaining tissue homeostasis. Dysregulation of TNF-R1 signaling has been implicated in various pathological conditions, including autoimmune diseases and cancer, making TNF-R1 a significant target for therapeutic intervention. Anti-TNF-R1 antibody (G-2) is essential for researchers studying these pathways, providing a reliable tool for the detection and analysis of TNF-R1 in diverse biological contexts.

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TNF-R1 Antibody (G-2) References:

1. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.  |  Grell, M., et al. 1999. EMBO J. 18: 3034-43. PMID: 10357816
2. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation.  |  Devin, A., et al. 2000. Immunity. 12: 419-29. PMID: 10795740
3. Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.  |  Melnick, M., et al. 2001. Anat Rec. 262: 318-30. PMID: 11241200
4. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.  |  Fotin-Mleczek, M., et al. 2002. J Cell Sci. 115: 2757-70. PMID: 12077366
5. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue.  |  Ermert, M., et al. 2003. Cytokine. 22: 89-100. PMID: 12849708
6. EMAP-II facilitates TNF-R1 apoptotic signalling in endothelial cells and induces TRADD mobilization.  |  van Horssen, R., et al. 2006. Apoptosis. 11: 2137-45. PMID: 17051333
7. TNF-alpha increases protein content in C2C12 and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK.  |  Plaisance, I., et al. 2008. Am J Physiol Endocrinol Metab. 294: E241-50. PMID: 17971516
8. Compartmentalization of TNF-receptor 1 signaling: TNF-R1-associated caspase-8 mediates activation of acid sphingomyelinase in late endosomes.  |  Bertsch, U., et al. 2011. Adv Exp Med Biol. 691: 605-16. PMID: 21153367
9. Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response.  |  Yang, Y., et al. 2011. Clin Exp Immunol. 165: 372-82. PMID: 21668898
10. TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.  |  Pattison, MJ., et al. 2016. Biochem J. 473: 2845-61. PMID: 27402796

The preferred TNF-R1 antibody is TNF-R1 Antibody (H-5): sc-8436.