TGF alpha Antibody (134 A): sc-36
- TGFα Antibody (134 A) is a mouse monoclonal IgG1, cited in 38 publications, provided at 100 µg/ml
- raised against recombinant TGFα protein of human origin
- recommended for detection of precursor and mature TGFα of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TGFα Antibody (134 A). This work is in progress.
TGFα Antibody (134 A) is a mouse monoclonal IgG1 antibody that detects transforming growth factor-α (TGFα) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TGFα is a crucial 50 amino acid protein that plays a significant role in cell signaling and growth regulation, particularly in the context of cancer. TGFα binds to the epidermal growth factor receptor (EGFR), leading to the activation of downstream signaling pathways that promote cell proliferation and survival. This interaction contributes to the development and progression of various malignancies, making TGFα a potential target for therapeutic intervention. TGFα is secreted by transformed cells, tumors, and some normal adult cells, indicating involvement in both physiological and pathological processes. TGFα bioactivity in the urine of cancer patients underscores relevance as a biomarker for malignancy, suggesting function as an autocrine growth factor that supports tumor growth and maintenance. TGFα mediates critical cellular functions and serves as a vital protein for researchers studying cancer biology and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TGF alpha Antibody (134 A) References:
- Expression of TGFalpha in meningiomas. | Halper, J., et al. 1999. J Neurooncol. 45: 127-34. PMID: 10778728
- Transforming growth factor alpha: a promoter of motoneuron survival of potential biological relevance. | Boillée, S., et al. 2001. J Neurosci. 21: 7079-88. PMID: 11549718
- Regulation of TGF-alpha expression in human keratinocytes: PKC-dependent and -independent pathways. | Klein, SB., et al. 1992. J Cell Physiol. 151: 326-36. PMID: 1572907
- Activator protein 2alpha mediates parathyroid TGF-alpha self-induction in secondary hyperparathyroidism. | Arcidiacono, MV., et al. 2008. J Am Soc Nephrol. 19: 1919-28. PMID: 18579641
- High serum TGF-α predicts poor response to lapatinib and capecitabine in HER2-positive breast cancer. | Rhee, J., et al. 2011. Breast Cancer Res Treat. 125: 107-14. PMID: 20936340
- TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells. | Wright, SE., et al. 2014. Oncol Lett. 7: 2113-2117. PMID: 24932299
- Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. | Brachmann, R., et al. 1989. Cell. 56: 691-700. PMID: 2645058
- TGFα expression in myeloid malignancies. | Kavanagh, S., et al. 2016. J Clin Pathol. 69: 543-6. PMID: 26984929
- TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia. | Dai, X., et al. 2020. J Cereb Blood Flow Metab. 40: 639-655. PMID: 30834805
- Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor-receptor (EGF-R) immunoreactivity in normal and pathologic brain. | Ferrer, I., et al. 1996. Prog Neurobiol. 49: 99-123. PMID: 8844822
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TGFα Antibody (134 A) | sc-36 | 100 µg/ml | $322.00 |