TCR Antibody (H57-597): sc-18904
- TCR Antibody (H57-597) is a Armenian hamster monoclonal IgG, cited in 3 publications, provided at 200 µg/ml
- raised against affinity purified murine T cell receptor
- recommended for detection of a common epitope of the β chain of the T-cell Receptor (TCR) complex on α/β TCR expressing T lymphocytes and thymocytes of mouse origin by IP, IF and FCM; non cross-reactive with gd TCR-bearing T cells
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for stimulation of T cells, sc-18904 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCR Antibody (H57-597). This work is in progress.
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SEE ALSO...
TCR Antibody (H57-597) is a hamster monoclonal IgG antibody that detects T cell antigen receptor (TCR) in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-TCR antibody (H57-597) specifically recognizes TCR, a crucial component of the adaptive immune response, which plays a vital role in identifying and responding to foreign antigens. TCR is a heterodimer that can be composed of either alpha and beta chains or gamma and delta chains, with the alpha/beta form being predominant in approximately 95% of circulating T cells. This receptor is essential for T cell activation, as TCR transmits signals that lead to the differentiation and proliferation of T cells upon antigen recognition. TCR is expressed on T helper and T cytotoxic cells, which can be distinguished by their respective CD4 and CD8 co-receptors. CD4 enhances the interaction between TCR and class II major histocompatibility complex (MHC) molecules, thereby increasing the efficiency of T cell activation. Understanding the structure and function of TCR is critical for developing targeted immunotherapies and vaccines, as TCR directly influences the immune system′s ability to recognize and eliminate pathogens.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCR Antibody (H57-597) References:
- T cell antigen-receptor signal transduction. | van Leeuwen, JE. and Samelson, LE. 1999. Curr Opin Immunol. 11: 242-8. PMID: 10375551
- The versatility of the αβ T-cell antigen receptor. | Bhati, M., et al. 2014. Protein Sci. 23: 260-72. PMID: 24375592
- Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains. | Beck-García, K., et al. 2015. Biochim Biophys Acta. 1853: 802-9. PMID: 25535948
- Membrane nanodomains in T-cell antigen receptor signalling. | Nika, K. and Acuto, O. 2015. Essays Biochem. 57: 165-75. PMID: 25658352
- Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy. | Joshi, K., et al. 2022. Curr Opin Immunol. 74: 1-8. PMID: 34454284
- T cell receptor (TCR) signaling in health and disease. | Shah, K., et al. 2021. Signal Transduct Target Ther. 6: 412. PMID: 34897277
- Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. | Chen, Y., et al. 2022. Mol Cell. 82: 1278-1287.e5. PMID: 35271814
- Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets. | Laletin, V., et al. 2023. J Immunother Cancer. 11: PMID: 37217244
- One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication. | Wolf, SP., et al. 2024. Clin Cancer Res. 30: 1642-1654. PMID: 38190111
- Structure of a fully assembled γδ T cell antigen receptor. | Gully, BS., et al. 2024. Nature. 634: 729-736. PMID: 39146975
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR Antibody (H57-597) | sc-18904 | 200 µg/ml | $322.00 | |||
TCR Antibody (H57-597) FITC | sc-18904 FITC | 200 µg/ml | $336.00 | |||
TCR Antibody (H57-597) L | sc-18904 L | 200 µg/0.1 ml | $322.00 | |||
TCR Antibody (H57-597) PE | sc-18904 PE | 200 µg/ml | $349.00 |