TCF-19 Antibody (H-2): sc-390923
- TCF-19 Antibody (H-2) is a mouse monoclonal IgG2a κ TCF-19 antibody provided at 200 µg/ml
- raised against amino acids 14-160 mapping within an internal region of TCF-19 of human origin
- TCF-19 Antibody (H-2) is recommended for detection of TCF-19 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TCF-19 Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TCF-19 Antibody (H-2) for WB applications. These reagents are now offered in bundles with TCF-19 Antibody (H-2) (see ordering information below).
TCF-19 Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TCF-19 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCF-19 (H-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TCF-19 protein, also known as transcription factor 19 or SC1, is a 345 amino acid protein characterized by one forkhead-associated (FHA) domain, a proline-rich domain, and one PHD-type zinc finger. TCF-19 is primarily localized in the nucleus, where TCF-19 functions as a growth-regulated trans-activating factor involved in transcription of genes governing late stages of cell cycle progression, particularly G1 to S phase transition and entry into G2 and mitosis. TCF-19 expression notably increases during G1-S phase of the cell cycle, highlighting TCF-19′s importance in regulating cellular proliferation. Additionally, TCF-19 gene is situated in a critical region on chromosome 6 linked to psoriasis vulgaris, a skin disorder characterized by epidermal cell hyperproliferation. This association suggests TCF-19′s potential influence on psoriasis development through regulatory effects on late cell cycle-specific genes, making TCF-19 a significant target for research in cell cycle regulation and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCF-19 Antibody (H-2) References:
- Genome sequencing analysis of the 1.8 Mb entire human MHC class I region. | Shiina, T., et al. 1999. Immunol Rev. 167: 193-9. PMID: 10319261
- Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. | Oka, A., et al. 1999. Hum Mol Genet. 8: 2165-70. PMID: 10545595
- Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. | Teraoka, Y., et al. 2000. Tissue Antigens. 55: 206-11. PMID: 10777095
- Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. | Nair, RP., et al. 2006. Am J Hum Genet. 78: 827-851. PMID: 16642438
- A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. | Ku, DH., et al. 1991. Cell Growth Differ. 2: 179-86. PMID: 1868030
- Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes. | Krishnan, BR., et al. 1995. Genomics. 30: 53-8. PMID: 8595903
- Identification of new HLA class I region genes by sample sequencing. | Goldsworthy, M., et al. 1997. Immunogenetics. 46: 206-12. PMID: 9211746
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCF-19 Antibody (H-2) | sc-390923 | 200 µg/ml | $322.00 | |||
TCF-19 Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-530303 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCF-19 Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-523735 | 200 µg Ab, 40 µg BP | $361.00 | |||
TCF-19 Antibody (H-2): m-IgG2a BP-HRP Bundle | sc-547477 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCF-19 Antibody (H-2) AC | sc-390923 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TCF-19 Antibody (H-2) HRP | sc-390923 HRP | 200 µg/ml | $322.00 | |||
TCF-19 Antibody (H-2) FITC | sc-390923 FITC | 200 µg/ml | $336.00 | |||
TCF-19 Antibody (H-2) PE | sc-390923 PE | 200 µg/ml | $349.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 488 | sc-390923 AF488 | 200 µg/ml | $364.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 546 | sc-390923 AF546 | 200 µg/ml | $364.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 594 | sc-390923 AF594 | 200 µg/ml | $364.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 647 | sc-390923 AF647 | 200 µg/ml | $364.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 680 | sc-390923 AF680 | 200 µg/ml | $364.00 | |||
TCF-19 Antibody (H-2) Alexa Fluor® 790 | sc-390923 AF790 | 200 µg/ml | $364.00 |