T-type Ca⁺⁺ CP α1H Antibody (G-10): sc-377510

T-type Ca++ CP α1H Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects T-type Ca++ CP alpha 1H protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). T-type Ca++ CP α1H (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. T-type Ca++ CP alpha 1H protein, also known as CACNA1H or Cav3.2, plays a crucial role in regulating calcium ion entry into excitable cells, which is essential for numerous physiological processes such as muscle contraction, neurotransmitter release, and gene expression. CACNA1H is primarily located in the plasma membrane of neurons and muscle cells, where CACNA1H contributes to generating low-threshold calcium currents vital for initiating action potentials. The unique biophysical properties of T-type calcium channels allow activation at relatively hyperpolarized membrane potentials, making these channels critical for modulating neuronal excitability and cardiac function. T-type channels are implicated in various pathophysiological conditions, including epilepsy and cardiac arrhythmias, highlighting their significance as potential therapeutic targets.

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T-type Ca⁺⁺ CP α1H Antibody (G-10) References:

1. Structure and regulation of voltage-gated Ca2+ channels.  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
2. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.  |  Davare, MA., et al. 2001. Science. 293: 98-101. PMID: 11441182
3. CaV3.2 T-type channels mediate Ca²⁺ entry during oocyte maturation and following fertilization.  |  Bernhardt, ML., et al. 2015. J Cell Sci. 128: 4442-52. PMID: 26483387
4. The voltage gated Ca(2+)-channel Cav3.2 and therapeutic responses in breast cancer.  |  Pera, E., et al. 2016. Cancer Cell Int. 16: 24. PMID: 27034617
5. Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy.  |  Souza, IA., et al. 2019. Mol Brain. 12: 86. PMID: 31651342
6. Cav3.2 T-type calcium channels control acute itch in mice.  |  Gadotti, VM., et al. 2020. Mol Brain. 13: 119. PMID: 32873320
7. Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain.  |  Fayad, SL., et al. 2022. Elife. 11: PMID: 36416409
8. Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels.  |  Martins, DF., et al. 2023. Mol Brain. 16: 60. PMID: 37464359
9. Effect of ABT-639 on Cav3.2 channel activity and its analgesic actions in mouse models of inflammatory and neuropathic pain.  |  Antunes, FTT., et al. 2024. Eur J Pharmacol. 967: 176416. PMID: 38342359
10. Cav3.2 deletion attenuates nonalcoholic fatty liver disease in mice.  |  Li, X., et al. 2024. Gene. 929: 148812. PMID: 39116959
11. Molecular biology of calcium channels.  |  Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
12. The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?  |  Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-T-type Ca⁺⁺ CP α1H Antibody (G-10) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-T-type Ca⁺⁺ CP α1H Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

T-type Ca⁺⁺ CP α1H Antibody (G-10) Specifications

Alternate Product Name: CACNA1H

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2174-2353

Epitope Target: T-type Ca⁺⁺ CP α1H

Epitope Species: human

Product Reactivity/Detection: T-type Ca⁺⁺ CP α1H

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for T-type Ca⁺⁺ CP α1H Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin