ST8Sia VI Antibody (E-3): sc-514631

ST8Sia VI Antibody (E-3) is a mouse monoclonal IgM antibody that detects ST8Sia VI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ST8Sia VI antibody (E-3) is available as a non-conjugated format. ST8Sia VI, also known as alpha-2,8-sialyltransferase 8F variant 3, plays a crucial role in the biosynthesis of sialylated glycoconjugates, which are essential for various biological processes, including cell-cell interactions, immune response modulation, and cellular integrity maintenance. ST8Sia VI is primarily located in the Golgi apparatus, where ST8Sia VI functions as a single-pass type II membrane protein, facilitating sialic acid transfer to O-glycans, thereby influencing glycoproteins and glycolipids structural diversity and functionality. ST8Sia VI′s location in the Golgi apparatus is critical as glycosylation occurs there, and dysregulation can lead to various diseases, including cancer and neurodegenerative disorders. ST8Sia VI shows highest expression levels in the kidney and is encoded by a gene located on human chromosome 10p12.33, making ST8Sia VI a vital component in the sialyltransferase family of twenty characterized members, each contributing to glycan structures regulation on cell surfaces.

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ST8Sia VI Antibody (E-3) References:

1. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans.  |  Takashima, S., et al. 2002. J Biol Chem. 277: 24030-8. PMID: 11980897
2. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.  |  Harduin-Lepers, A., et al. 2005. Glycobiology. 15: 805-17. PMID: 15843597
3. Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.  |  Teintenier-Lelièvre, M., et al. 2005. Biochem J. 392: 665-74. PMID: 16120058
4. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.  |  Avril, T., et al. 2006. J Leukoc Biol. 80: 787-96. PMID: 16857734
5. Characterization of mouse sialyltransferase genes: their evolution and diversity.  |  Takashima, S. 2008. Biosci Biotechnol Biochem. 72: 1155-67. PMID: 18460788
6. Comparative sequence analysis in the sialyltransferase protein family: analysis of motifs.  |  Datta, AK. 2009. Curr Drug Targets. 10: 483-98. PMID: 19519350

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ST8Sia VI Antibody (E-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ST8Sia VI Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ST8Sia VI Antibody (E-3) Specifications

Alternate Product Name: ST8Sia VI

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 165-187

Epitope Target: ST8Sia VI

Epitope Species: human

Product Reactivity/Detection: ST8Sia VI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ST8Sia VI Antibody (E-3): P: Blocking Peptide