Sm D1 Antikörper (A-9): sc-166650

Sm D1 Antibody (A-9) is a high quality monoclonal Sm D1 antibody (also designated SNRPD1 antibody, SMD1 antibody, Small Nuclear Ribonucleoprotein D1 Polypeptide antibody, Sm-D1 antibody, SnRNP Core Protein D1 antibody, Sm-D Autoantigen antibody, Small Nuclear Ribonucleoprotein D1 Polypeptide (16kD) antibody, or SNRPD antibody) suitable for the detection of the Sm D1 protein of mouse, rat and human origin. Sm D1 Antibody (A-9) is available as both the non-conjugated anti-Sm D1 antibody form, as well as multiple conjugated forms of anti-Sm D1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. U1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes. Each UsnRNP contains common Sm proteins B/B′, D1, D2, D3, E, F and G. The Sm proteins pair up as D1-D2, B/B′-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm. Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. Sm D1, D2 and D3 are present in U1, U2, U4/5 and U5 but not U7 snRNPs in human and mouse cells. U7 snRNPs contain Lsm10, an Sm D1-like protein. Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B/B′, D1 and D3. The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA